RT info:eu-repo/semantics/article
T1 Inherent antibacterial activity and in vitro biocompatibility of hydrophilic polymer film containing chemically anchored sulfadiazine moieties
A1 Morro, Ana
A1 Abrusci, Concepción
A1 Pablos, Jesús Luis
A1 Marín, Irma
A1 García García, Félix Clemente
A1 García Pérez, José Miguel
K1 PVP
K1 Sulfadiazine
K1 Antibacterial polymer
K1 Biocompatible
K1 Chemistry
K1 Química
AB Microbial colonisation of synthetic materials is a great concern in many fields, e.g., in implant surgery and medical devices; therefore biocompatible hydrophilic organic materials with inherent antimicrobial properties are of current research interest. In this work, we describe the preparation of antibacterial and biocompatible polymeric film based on N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl acrylate (HEA), using ethyleneglycol dimethacrylate (EGDMA), and synthetic acrylic monomer containing sulfadiazine chemically anchored. The synthesised polyvinylpyrrolidone (PVP)-based films were characterized by different techniques (1H and 13C NMR, ATR-FTIR, SEM, and TGA). In this study, the biophysical responses of bacteria and L929 cells towards the prepared materials as model device surfaces were evaluated. The membrane that contains the anchored sulfadiazine moiety showed excellent antibacterial activity against Escherichia coli as well as good biocompatibility. Based on the experimental results, this material is a good candidate for medical applications as a biomaterial.
PB Elsevier
YR 2017
FD 2017-06
LK http://hdl.handle.net/10259/4436
UL http://hdl.handle.net/10259/4436
LA eng
NO Spanish Ministerio de Economía y Competitividad-Feder(MAT2014-54137-R and MAT2012-31709) and by the Consejería de Educación – Junta de Castilla y León – Feder (BU061U16)
DS Repositorio Institucional de la Universidad de Burgos
RD 21-nov-2024