RT info:eu-repo/semantics/article
T1 Thermal denaturation of A-DNA
A1 Valle Orero, J.
A1 Wildes, Andew R.
A1 Theodorakopoulos, Nikos
A1 Cuesta López, Santiago
A1 Garden, J. L. .
A1 Danilkin, S. .
A1 Peyrard, Michel
K1 Física
K1 Physics
AB The DNA molecule can take various conformational forms. Investigationsfocus mainly on the so-called ‘B-form’, schematically drawn in the famouspaper by Watson and Crick [1]. This is the usual form of DNA in a biologicalenvironment and is the only form that is stable in an aqueous environment.Other forms, however, can teach us much about DNA. They have the samenucleotide base pairs for ‘building blocks’ as B-DNA, but with differentrelative positions, and studying these forms gives insight into the interactionsbetween elements under conditions far from equilibrium in the B-form.Studying the thermal denaturation is particularly interesting because it providesa direct probe of those interactions which control the growth of thefluctuations when the ‘melting’ temperature is approached. Here we reportsuch a study on the ‘A-form’ using calorimetry and neutron scattering. Weshow that it can be carried further than a similar study on B-DNA, requiringthe improvement of thermodynamic models for DNA.
PB IOP Publising
SN 1367-2630
YR 2014
FD 2014-11
LK http://hdl.handle.net/10259/4768
UL http://hdl.handle.net/10259/4768
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 26-abr-2024