RT info:eu-repo/semantics/article T1 Polymeric chemosensor for the detection and quantification of chloride in human sweat. Application to the diagnosis of cystic fibrosis A1 Vallejos Calzada, Saúl A1 Hernando Santa Cruz, Elsa A1 Trigo López, Miriam A1 García García, Félix Clemente A1 García Valverde, María A1 Iturbe, David . A1 Cabero, María Jesús . A1 Quesada Pato, Roberto A1 García Pérez, José Miguel K1 Chemistry, Organic K1 Química orgánica AB We have developed a new extremely hydrophilic polymeric film suitable for the detection and quantification of chloride in human sweat directly on the skin. The film, or membrane, has chemically anchored 6-methoxyquinoline groups as chloride responsive fluorescent motifs. We have prepared the sensory material from a standard vinyl copolymer, by a convenient and easy solid-phase reaction. The sensory material has a water swelling percentage of 700%, facilitating an immediate detection of chloride, is reusable for at least 6 cycles and can be handled without care by unskilled persons. The initially high fluorescence of the material decreases in the presence of chloride, allowing the quantification of chloride concentration by using the colour definition of a digital picture or a fluorimeter. The suitability of the material to perform quantitative chloride analysis of human sweat by putting it in contact with the skin offers promise for its application in the sweat test used for the diagnosis of cystic fibrosis (CF). PB Royal Society of Chemistry SN 2050-750X YR 2018 FD 2018-06 LK http://hdl.handle.net/10259/4815 UL http://hdl.handle.net/10259/4815 LA eng NO FEDER and both the SpanishMinisterio de Economía y Competitividad (MAT2014-54137-Rand MAT2017-84501-R) and the Consejería de Educación –Junta de Castilla y León (BU092U16 and BU061U16) DS Repositorio Institucional de la Universidad de Burgos RD 28-mar-2024