RT info:eu-repo/semantics/article T1 Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs A1 Hernando Santa Cruz, Elsa A1 Soto Cerrato, Vanessa A1 Cortés Arroyo, Susana . A1 Pérez Tomás, Ricardo A1 Quesada Pato, Roberto K1 Química orgánica K1 Chemistry, Organic AB Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, havebeen synthesized. These compounds proved to be highly efficient transmembrane anion transporters inmodel liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or thealkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity ofthese compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50values in the low micromolar range as well as modify the intracellular pH, inducing the basification ofacidic organelles. PB Royal Society of Chemistry SN 1477-0520 YR 2014 FD 2014-03 LK http://hdl.handle.net/10259/4876 UL http://hdl.handle.net/10259/4876 LA eng NO Consejería de Educación de la Junta de Castilla y León (ProjectBU340U13) and Fundació la Maratón de TV3. DS Repositorio Institucional de la Universidad de Burgos RD 28-mar-2024