RT info:eu-repo/semantics/article
T1 Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs
A1 Hernando Santa Cruz, Elsa
A1 Soto Cerrato, Vanessa
A1 Cortés Arroyo, Susana .
A1 Pérez Tomás, Ricardo
A1 Quesada Pato, Roberto
K1 Química orgánica
K1 Chemistry, Organic
AB Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, havebeen synthesized. These compounds proved to be highly efficient transmembrane anion transporters inmodel liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or thealkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity ofthese compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50values in the low micromolar range as well as modify the intracellular pH, inducing the basification ofacidic organelles.
PB Royal Society of Chemistry
SN 1477-0520
YR 2014
FD 2014-03
LK http://hdl.handle.net/10259/4876
UL http://hdl.handle.net/10259/4876
LA eng
NO Consejería de Educación de la Junta de Castilla y León (ProjectBU340U13) and Fundació la Maratón de TV3.
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024