RT info:eu-repo/semantics/article
T1 Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines
A1 García Tojal, Javier
A1 Gil García, Rubén
A1 Fouz Cuesta, Víctor Ivo
A1 Madariaga, Gotzon
A1 Lezama, Luis
A1 Galletero, María S.
A1 Borrás, Joaquín
A1 Nollmann, Friederike I.
A1 García Girón, Carlos
A1 Alcaraz, Raquel
A1 Cavia Saiz, Mónica
A1 Muñiz Rodríguez, Pilar
A1 Palacios, Óscar
A1 Samper, Katia G.
A1 Rojo, Teófilo
K1 Colon carcinoma
K1 Copper
K1 Molecular magnetism
K1 Thiosemicarbazone
K1 Química inorgánica
K1 Chemistry, Inorganic
K1 Aparato digestivo-Enfermedades
K1 Digestive organs-Diseases
AB Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to thepotential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes restson their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the[Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopicand magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu(PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show theabsence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement withthe release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochromec and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared withthose shown by the free HPTSC and HPTSC* ligands.
PB Elsevier
SN 0162-0134
YR 2018
FD 2018-03
LK http://hdl.handle.net/10259/4929
UL http://hdl.handle.net/10259/4929
LA eng
NO Obra Social “laCaixa” (OSLC-2012-007), Ministerio de Economía y Competitividad andFEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371-REDT,MAT2015-66441-P, BIO2015-67358-C2-2-P), Junta de Castilla y León(BU237U13), Gerencia Regional de Salud, Consejería de Sanidad, Juntade Castilla y León (GRS 1023/A/14), the Basque Government (projectIT-779-13)
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024