RT info:eu-repo/semantics/article
T1 Tissue specific expression of human fatty acid oxidation enzyme genes in late pregnancy
A1 Bartha, Jose L. .
A1 Bugatto, Fernando .
A1 Fernández Deudero, Álvaro .
A1 Fernández Macías, Rosa .
A1 Perdomo Hernández, Germán M.
K1 Fatty acid metabolism
K1 Long-chain acyl CoA dehydrogenase
K1 Medium-chain acyl CoA dehydrogenase
K1 Placenta
K1 Obstetricia
K1 Obstetrics
AB Background: Abnormal fatty acid oxidation (FAO) is associated with maternal and fetal complications duringpregnancy. The contribution of maternal and fetal tissues to FAO capacity during late pregnancy is important tounderstand the pathophysiology of pregnancy-associated complications. The aim of this study was to determinethe expression levels of mitochondrial FAO enzymes in maternal and fetal tissues during late normal pregnancy.Methods: We have measured by Real-time PCR the levels of long- and medium -chain acyl-CoA dehydrogenase(LCHAD and MCAD), two acyl-CoA dehydrogenases that catalyze the initial step in the mitochondrial FAO spiral.Results: LCHAD and MCAD were expressed in maternal skeletal muscle, subcutaneous adipose tissue, placenta, andmaternal and fetal blood cells. LCHAD gene expression was four- to 16-fold higher than MCAD gene expression inplacenta, adipose tissue and skeletal muscle. In contrast, MCAD gene expression was ~5-fold higher in fetal bloodthan maternal blood (p = 0.02), whereas LCHAD gene expression was similar between fetal blood and maternalblood (p =0.91).Conclusions: LCHAD and MCAD are differentially expressed in maternal and fetal tissues during normal latepregnancy, which may represent a metabolic adaptation in response to physiological maternal dyslipidemia duringlate pregnancy.
PB BioMed Central
SN 1476-511X
YR 2016
FD 2016-11
LK http://hdl.handle.net/10259/4995
UL http://hdl.handle.net/10259/4995
LA eng
NO Consejeria de Salud, Junta de Andalucía Num Expte: 0269/05.
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024