RT info:eu-repo/semantics/article
T1 Strong influence of the ancillary ligand over the photodynamic anticancer properties of neutral biscyclometalated IrIII complexes bearing 2‐benzoazole‐phenolates
A1 Martínez Alonso, Marta
A1 Busto Vázquez, Natalia
A1 Aguirre, Larry Danilo
A1 Berlanga, Leticia
A1 Carrión, María C. .
A1 Cuevas Vicario, José Vicente
A1 Rodríguez, Ana M. .
A1 Carbayo Martín, Mª Aránzazu
A1 Manzano, Blanca R. .
A1 Ortí, Enrique .
A1 Jalón, Félix A.
A1 García Ruiz, Begoña
A1 Espino Ordóñez, Gustavo
K1 2-arylazoles
K1 anticancercomplexes
K1 heterolepticneutraliridium(III)complexes
K1 phosphorescent complexes
K1 photodynamictherapy
K1 Química
K1 Chemistry
AB In this paper, the synthesis, comprehensive characterization and biological and photocatalytic properties of two series of neutral IrIII biscyclometalated complexes of general formula [Ir(C^N)2(N^O)], where the N^O ligands are 2‐(benzimidazolyl)phenolate‐N,O (L1, series a) and 2‐(benzothiazolyl)phenolate‐N,O (L2, series b), and the C^N ligands are 2‐(phenyl)pyridinate or its derivatives, are described,. Complexes of types a and b exhibit dissimilar photophysical and biological properties. In vitro cytotoxicity tests conclusively prove that derivatives of series a are harmless in the dark against SW480 cancer cells (colon adenocarcinoma), but express enhanced cytotoxicity versus the same cells after stimulation with UV or blue light. In contrast, complexes of type b show a very high cytotoxic activity in the dark, but low photosensitizing ability. Thus, the ancillary N^O ligand is the main factor in terms of cytotoxic activity both in the dark and upon irradiation. However, the C^N ligands play a key role regarding cellular uptake. In particular, the complex of formula [Ir(dfppy)2(L1)] (dfppy=2‐(4,6‐difluorophenyl)pyridinate) [3 a] has been identified as both an efficient photosensitizer for 1O2 generation and a potential agent for photodynamic therapy. These capabilities are probably related to a combination of its notable cellular internalization, remarkable photostability, high photoluminescence quantum yield, and long triplet excited‐state lifetime. Both types of complexes exhibit notable catalytic activity in the photooxidation of thioanisole and S‐containing aminoacids with full selectivity.
PB Wiley-VCH Verlag
SN 0947-6539
YR 2018
FD 2018-11
LK http://hdl.handle.net/10259/5041
UL http://hdl.handle.net/10259/5041
LA eng
NO SpanishMinisteriode Econom&ayCompetitividad-FEDER(CTQ2014-58812-C2-1-Rand CTQ2014-58812-C2-2-R,CTQ2015-70371-REDT,CTQ2015-71353-R,CTQ2015-71154-P,and Unidadde Excelencia Mar&adeMaeztuMDM-2015-0538),the Conseje-r&adeEducacijn-Juntade CastillayLejn-FEDER(BU299A12-1,BU042U16and BU051U16).The Generalitat Valenciana(Prome-teo2016/135),andthe “la Caixa”Foundation(LCF/PR/PR12/11070003)
DS Repositorio Institucional de la Universidad de Burgos
RD 22-dic-2024