RT info:eu-repo/semantics/article
T1 Synthesis, crystal structure and cytotoxicity assays of a copper(II) nitrate complex with a tridentate ONO acylhydrazone ligand. Spectroscopic and theoretical studies of the complex and its ligand
A1 Burgos López, Y.
A1 Plá, Julián del
A1 Balsa, Lucía M.
A1 León, Ignacio E.
A1 Echeverría, Gustavo A.
A1 Piro, Oscar Enrique
A1 García Tojal, Javier
A1 Pis Diez, Reinaldo
A1 González Baró, Ana C.
A1 Parajón Costa, Beatriz S.
K1 Cu(II)-complex
K1 Hydrazones
K1 Spectroscopy
K1 Crystal structure
K1 DFT calculations
K1 Anticancer activity
K1 Química inorgánica
K1 Chemistry, Inorganic
AB The new copper complex, [Cu(HL)(OH2)2](NO3), including the tridentate N-acyhydrazone derived from 4-hydroxy-benzohydrazide and 2-hydroxy-3-methoxybenzaldehyde, (H2L), has been synthesized and characterized in the solid state and in solution by spectroscopic (FTIR, Ra, UV–vis, EPR) methods. The results were compared with those obtained for the hydrazone ligand and complemented with computational methods based on DFT. The crystal structure of the complex has been determined by X-ray diffraction. It crystallizes in the triclinic  space group with Z = 2. The Cu(II) ion is in a distorted square pyramidal environment, coordinated to a planar HL- anion acting as a tridentate ligand. The 5-fold coordination is completed with two water molecules. It is arranged in the lattice as H-bonded ribbon-like polymers that extends along the [1 2 1] crystal direction. The cytotoxicity of the complex together with that of the H2L ligand and the copper ion were evaluated in vitro against five different human cancer cell lines namely A549 (lung), MG-63 (bone), MCF-7 and MDA-MB-231 (breast) and Jurkat (leukemia). The copper complex inhibits the cell viability in a dose dependent manner with a greater potency than the H2L ligand and the free copper ion displaying even higher antitumor activity than the well-known anticancer metallodrug cisplatin.
PB Elsevier
SN 0020-1693
YR 2019
FD 2019-03
LK http://hdl.handle.net/10259/5085
UL http://hdl.handle.net/10259/5085
LA eng
NO CONICET (PIP 11220130100651CO and PIP 0034), UNLP (111/X673) and ANPCyT (PICT 2014-2223) of Argentina. Consejería de Educación CyL and FFEDER BU076U16, BU022G18 and Ministerio de Economía y Competitividad CTQ2016-75023-C2-1-P and CTQ2015-70371-REDTMetDrugs Network (Spain)
DS Repositorio Institucional de la Universidad de Burgos
RD 04-dic-2024