RT info:eu-repo/semantics/article
T1 Reductive molybdenum‐catalyzed direct amination of boronic acids with nitro compounds
A1 Suárez Pantiga, Samuel
A1 Hernández Ruiz, Raquel
A1 Virumbrales Ortiz, Cintia
A1 Pedrosa Sáez, María de los Remedios
A1 Sanz Díez, Roberto
K1 amination
K1 boronic acids
K1 molybdenum
K1 nitro compounds
K1 reduction
K1 Química orgánica
K1 Chemistry, Organic
AB The synthesis of aromatic amines is of utmost importance in a wide range of chemical contexts. We report a direct amination of boronic acids with nitro compounds to yield (hetero)aryl amines. The novel combination of a dioxomolybdenum(VI) catalyst and triphenylphosphine as inexpensive reductant has revealed to be decisive to achieve this new C-N coupling. Our methodology has proven to be scalable, air and moisture tolerant, highly chemoselective and engages both aliphatic and aromatic nitro compounds. More-over, this general and step-economical synthesis of aromatic secondary amines show cases orthogonality to other aromatic secondary amines show cases orthogonality to other aromatic amine syntheses as it tolerates aryl halides and carbonyl compounds.
PB Wiley
SN 1433-7851
YR 2019
FD 2019-02
LK http://hdl.handle.net/10259/5178
UL http://hdl.handle.net/10259/5178
LA spa
NO Junta de Castilla y León (BU022G18),Junta de Castilla y León and FEDER (BU076U16 and BU291P18) and Ministerio de Economía y Competitividad (MINECO) (CTQ2016-75023-C2-1-P)
DS Repositorio Institucional de la Universidad de Burgos
RD 22-nov-2024