RT info:eu-repo/semantics/article
T1 Cu(ii) and Zn(ii) complexes with a poly-functional ligand derived from o-vanillin and thiophene. Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
A1 Rodríguez, María R.
A1 Plá, Julián del
A1 Balsa, Lucía M.
A1 León, Ignacio E.
A1 Piro, Oscar Enrique
A1 Echeverría, Gustavo A.
A1 García Tojal, Javier
A1 Pis Diez, Reinaldo
A1 Parajón Costa, Beatriz S.
A1 González Baró, Ana C.
K1 Química inorgánica
K1 Chemistry, Inorganic
AB The interaction of a poly-functional ligand derived from o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by X-ray diffraction methods. Two molecules of the deprotonated ligand acting in a bidentate fashion build a nearly square planar environment around Cu(II) and a distorted tetrahedral coordination arrangement for Zn(II). The complexes were characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance and solution UV-vis and EPR. Their thermal behavior has been analyzed by means of TGA and DTA. DFT theoretical studies, using computational methods based on DFT, were employed to assist the interpretation and assignment of spectroscopic data. Cytotoxicity assays against two human breast cancer cell lines, namely MCF-7 and MDA-MB-231, revealed an enhancement of the effectiveness of the complexes as compared with both the ligand and the free metal ions. The results for the copper compound are promising, as its cytotoxic effect was stronger than the reference metallodrug cisplatin in both cancer cell lines tested.
PB Royal Society of Chemistry
SN 1144-0546
YR 2019
FD 2019-05
LK http://hdl.handle.net/10259/5201
UL http://hdl.handle.net/10259/5201
LA eng
NO CONICET-CCT-La Plata (PIP 0651 and 0034), ANPCyT (PICT 2016-1574) and UNLP (11/X-473) (Argentina) and also by Consejerı´a de Educacio´n CyL and FFEDER BU076U16, BU022G18 and Ministerio de Economı´a y Competitividad CTQ2016-75023-C2-1-P and CTQ2015-70371- REDT MetDrugs Network (Spain
DS Repositorio Institucional de la Universidad de Burgos
RD 22-dic-2024