RT info:eu-repo/semantics/article
T1 Intestinal fructose and glucose metabolism in health and disease
A1 Perdomo Hernández, Germán M.
A1 Merino, Beatriz
A1 Fernández Díaz, Cristina M. .
A1 Cózar Castellano, Irene
K1 fructose
K1 glucose
K1 small intestine
K1 liver
K1 brain
K1 gut-brain axis
K1 non-alcoholic fatty liver
K1 insulin resistance
K1 metabolic syndrome
K1 type 2 diabetes mellitus
K1 Endocrinología
K1 Endocrinology
AB The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed.
PB MDPI
YR 2020
FD 2020-01
LK http://hdl.handle.net/10259/5242
UL http://hdl.handle.net/10259/5242
LA eng
NO Spanish MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD, grant numbers SAF2016-77871-C2-1-R and SAF2016-77871-C2-2-R to I.C-C. and G.P. respectively; the EFSD European Research Programme on New Targets for Type 2 Diabetes supported by an educational research grant from MSD to I.C-C. and G.P.; the FUNDACIÓN LA-CAIXA Y FUNDACIÓN CAJA DE BURGOS, grant number CAIXA-UBU001 to G.P.
DS Repositorio Institucional de la Universidad de Burgos
RD 25-abr-2024