RT info:eu-repo/semantics/article
T1 Wine pomace product modulates oxidative stress and microbiota in obesity high-fat diet-fed rats
A1 Gerardi, Gisela
A1 Cavia Saiz, Mónica
A1 Rivero Pérez, Maria Dolores
A1 González San José, Mª Luisa
A1 Muñiz Rodríguez, Pilar
K1 High fat
K1 Obesity
K1 Polyphenols
K1 Wine pomace
K1 Wistar rats
K1 Microbiota
K1 Alimentos
K1 Food
K1 Bioquímica
K1 Biochemistry
K1 Biología molecular
K1 Molecular biology
AB Obesity is associated with inflammation and oxidative stress. Bioactive compounds can decrease obesity-related disorders by their antioxidant and anti-inflammatory actions. Wistar rats were fed with a high-fat diet during 14 weeks and received 100 mg of wine pomace product (WP)/kg body weight, from the 1st week or from the 7th week and standard diet fed rats were included. Food intake, body weight, blood pressure and plasma glucose, cholesterol and triglyceride were weekly measured. Antioxidant and lipid liver status, fat, adipocyte size, plasma interleukins and microbiota were also determined at 14th week. The results showed a significant reduction of body weight and abdominal fat area, lower blood glucose, decreased liver weight and lipids deposition with increased antioxidant status, lower adipocyte size and increased Lactobacillus spp./Bacteroides spp. ratio. Therefore, wine pomace product reduced obesity-related disorders by amelioration of inflammation and oxidative stress and by microbiota regulation suggesting potential preventive clinical benefits.
PB Elsevier
SN 1756-4646
YR 2020
FD 2020
LK http://hdl.handle.net/10259/5296
UL http://hdl.handle.net/10259/5296
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 20-abr-2024