RT info:eu-repo/semantics/article
T1 Wine pomace product ameliorates hypertensive and diabetic aorta vascular remodeling through antioxidant and anti-inflammatory actions
A1 Gerardi, Gisela
A1 Cavia Saiz, Mónica
A1 Pino García, Raquel del
A1 Rivero Pérez, Maria Dolores
A1 González San José, Mª Luisa
A1 Muñiz Rodríguez, Pilar
K1 Aorta
K1 Diabetes
K1 Hypertension
K1 Vascular remodeling
K1 eNOS
K1 Wine pomace product
K1 Alimentos
K1 Food
K1 Bioquímica
K1 Biochemistry
K1 Biología molecular
K1 Molecular biology
AB Vascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine pomace product (WP) on morphometric parameters of the arterial wall in spontaneously hypertensive rats (SHRs) and streptozotocin-diabetic rats (STZ). Oxidative stress was also evaluated by determination of radical oxygen species (ROS) and endothelial nitric oxide synthase (eNOS) activation in thoracic aortas. Wine pomace reduces wall aortic thickness, cross sectional area and wall/lumen ratio, and decreases ROS and increases eNOS activation. In summary, the supplementation of hypertensive or diabetic rats with the wine pomace product exhibits a protective role against the endothelial dysfunction and vascular remodeling.
PB Elsevier
SN 1756-4646
YR 2020
FD 2020-03
LK http://hdl.handle.net/10259/5299
UL http://hdl.handle.net/10259/5299
LA eng
NO Autonomous Government of Castilla y León (Research project BU282U13
DS Repositorio Institucional de la Universidad de Burgos
RD 19-abr-2024