RT info:eu-repo/semantics/article
T1 Why is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds
A1 Guembe García, Marta
A1 Peredo Guzmán, Patricia D.
A1 Santaolalla García, Victoria
A1 Moradillo Renuncio, Natalia
A1 Ibeas Cortes, Saturnino
A1 Mendía Jalón, Aránzazu
A1 García García, Félix Clemente
A1 García Pérez, José Miguel
A1 Vallejos Calzada, Saúl
K1 solid‐state chemosensors
K1 sensory polymers
K1 amino acids
K1 chronic wounds
K1 Química
K1 Chemistry
AB We anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) anda dye, to a polymer matrix obtaining film‐shaped chemosensors with induced selectivity towardglycine. This sensory material is exploited in the selectivity detection of glycine in complex mixturesof amino acids mimicking elastin, collagen and epidermis, and also in following the protease activityin a beefsteak and chronic human wounds. We use the term inducing because the probe in solutionis not selective toward any amino acid and we get selectivity toward glycine using the solid‐state.Overall, we found that the chemical behaviour of a chemical probe can be entirely changed bychanging its chemical environment. Regarding its behaviour in solution, this change has beenachieved by isolating the probe by anchoring the motifs in a polymer matrix, in an amorphous state,avoiding the interaction of one sensory motif with another. Moreover, this selectivity change can befurther tuned because of the effectiveness of the transport of targets both by the physical nature ofthe interface of the polymer matrix/solution, where the target chemicals are dissolved, for instance,and inside the matrix where the recognition takes place. The interest in chronic human wounds isrelated to the fact that our methods are rapid and inexpensive, and also considering that the proteaseactivity can correlate with the evolution of chronic wounds.
PB MDPI
YR 2020
FD 2020-06
LK http://hdl.handle.net/10259/5321
UL http://hdl.handle.net/10259/5321
LA eng
NO FEDER (Fondo Europeo de Desarrollo Regional), and both the Spanish Ministerio de Economía, Industria y Competitividad (MAT2017‐84501‐R) and the Consejería de Educación—Junta de Castilla y León (BU061U16)
DS Repositorio Institucional de la Universidad de Burgos
RD 11-dic-2024