RT info:eu-repo/semantics/article
T1 Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells
A1 Soto Cerrato, Vanessa
A1 Manuel Manresa, Pilar .
A1 Hernando Santa Cruz, Elsa
A1 Calabuig Fariñas, Silvia
A1 Martínez Romero, Alicia
A1 Fernández Dueñas, Víctor
A1 Sahlholm, Kristoffer
A1 Knöpfel, Thomas
A1 García Valverde, María
A1 Rodilla, Ananda M.
A1 Jantus Lewintre, Eloisa
A1 Farràs, Rosa
A1 Ciruela, Francisco
A1 Pérez Tomás, Ricardo
A1 Quesada Pato, Roberto
K1 Química orgánica
K1 Chemistry, Organic
AB Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.
PB American Chemical Society
SN 0002-7863
YR 2015
FD 2015-12
LK http://hdl.handle.net/10259/5370
UL http://hdl.handle.net/10259/5370
LA eng
NO panishgovernment and the EU (FIS PI13/00089, FIS PI12/02838,FIS PI12/00956 and RD12/0036/0025), a grant from LaMaratóde TV3 Foundation (20132730), a grant from SEPAR(17/2014), Consejería de Educación de la Junta de Castilla yLeón (Project BU340U13), Ministerio de Economíaycompetitividad/Instituto de Salud Carlos III (SAF2014-55700-P), and ICREA Academia-2010
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024