RT info:eu-repo/semantics/article
T1 Electrochemical detection of fentanyl with screen-printed carbon electrodes using square-wave adsorptive stripping voltammetry for forensic applications
A1 Ott, Colby E.
A1 Cunha Silva, Hugo
A1 Kuberski, Sara L
A1 Cox, Joseph A.
A1 Arcos Martínez, Julia
A1 Arroyo Mora, Luís E.
K1 Fentanyl
K1 Screen-printed electrodesFentanyl voltammetric determination
K1 Forensic science
K1 Oral fluid
K1 Seized drugs
K1 Química analítica
K1 Chemistry, Analytic
AB Square-wave adsorptive stripping voltammetry (SWAdSV) is proposed as a fast, simple, and sensitive approach toward the detection, identification, and semi-quantitation of fentanyl in seized drug samples using screen-printed carbon electrodes. Electrochemical oxidation of fentanyl resulted in the formation of two anodic peaks, one at 0.75 V (peak I) and the second at 0.88 V (peak II) versus a Ag/AgCl pseudo reference electrode. Voltammetric measurements were conducted under optimized experimental conditions using fentanyl standards ranging from 0.076 μg/mL to 6.9 μg/mL, which resulted in a limit of detection of 0.037 μg/mL. Reproducibility was assessed as the average percent relative standard deviation of the slopes of calibration curves and was 2.6% for oxidation peak I and 7.4% for oxidation peak II in cell. Detection capabilities were assessed in a 5-mL cell and in a 100 microliter drop. Interference studies were conducted with cocaine, methamphetamine, quinine, caffeine, and acetaminophen. The mechanism for the electrochemical oxidation of fentanyl to norfentanyl is also described. Accuracy and suitability of the method for seized drug analysis was assessed using 11 simulated samples. Suitability of the method for future analysis of fentanyl in oral fluid was assessed.
PB Elsevier
SN 1572-6657
YR 2020
FD 2020-09
LK http://hdl.handle.net/10259/5597
UL http://hdl.handle.net/10259/5597
LA eng
NO Awa the National Institute of Justice award 2019-DU-BX-0030. The opinions, findings and conclusions are those of the authors and do not necessarily reflects those of the Department of Justice. Funding was also provided by the Fundación Bancaria Caixa D. Estalvis I Pensions de Barcelona, La Caixa (DIABO-PIF-R00W05). Hugo Cunha-Silva would like to acknowledge funding from the Spanish Ministry of Economy and the European Regional Development Fund (FEDER) (BES-2014-068214).
DS Repositorio Institucional de la Universidad de Burgos
RD 19-abr-2024