RT info:eu-repo/semantics/article
T1 A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy†
A1 Ortega, Enrique
A1 Pérez Arnáiz, Cristina
A1 Rodríguez, Venancio
A1 Janiak, Christoph
A1 Busto Vázquez, Natalia
A1 García Ruiz, Begoña
A1 Ruiz, José
K1 Platinum(II) complexes
K1 Anticancer and antibacterial activity
K1 Photodynamic inhibition
K1 Photodynamic therapy
K1 Dual action agents
K1 Química física
K1 Chemistry, Physical and theoretical
AB Cancer and antibiotic resistance are two global health threats that usually hamper clinical chemotherapeutic efficacy. Particularly for lung cancer, bacterial infections frequently arise thereby complicating the course of cancer treatment. In this sense, three new neutral luminescent cycloplatinated(II) photosensitizers of the type [Pt(dmba)(L)] (dmba = N,N-dimethylbenzylamine-κN,κC; L = 2-(benzo[d]oxazol-2-yl)-phenolato-κN,κO 1, 2-(benzo[d]thiazol-2-yl)-phenolato-κN,κO 2, and 2-(1-methyl-1H-benzo[d]imidazole-2-yl)phenolato-κN,κO 3) have been characterized and developed to potentially eliminate both resistant bacteria and lung cancer cells. The phototherapeutic effects of complex 2 have been evaluated using low doses of blue light irradiation. Complex 2 exerted promising photoactivity against pathogenic Gram-positive bacteria strains of clinical interest, displaying a phototoxic index (PI) of 15 for methicillin-resistant Staphylococcus aureus, one of the major microorganisms predominating lung infections. Likewise, the anticancer activity of 2 was also increased upon light irradiation in human lung A549 cancer cells (PI = 36). Further in vitro experiments with this platinum(II) complex suggest that ROS-generating photodynamic reactions were involved upon light irradiation, thus providing a reasonable mechanism for its dual anticancer and antibacterial activities.
PB Elsevier
SN 0223-5234
YR 2021
FD 2021-10
LK http://hdl.handle.net/10259/5814
UL http://hdl.handle.net/10259/5814
LA eng
NO Spanish Ministerio de Ciencia e Innovación (MCI/AEI) and FEDER funds (Projects RTI2018-096891-B-I00, RTI2018-102040-B-100 and MultiMetDrugs network RED2018-102471-T), Consejería de Educación-Junta de Castilla y León-FEDER (BU042U16-BU305P18), “la Caixa” Banking Foundation (LCF/PR/PR12/11070003) and Fundación Séneca-Región de Murcia (Project 20857/PI/18). E.O. thanks AECC (PRDMU19003ORTE). Networking support by the COST Action CA18202
DS Repositorio Institucional de la Universidad de Burgos
RD 24-nov-2024