RT info:eu-repo/semantics/article T1 Can plasma α-Synuclein help us to differentiate parkinson’s disease from essential tremor? A1 Albillos García, Silvia María A1 Montero, Olimpio A1 Calvo Meruelo, Sara A1 Solano, Berta A1 Trejo Gabriel y Galán, José Mª A1 Cubo Delgado, Esther K1 Parkinson’s disease K1 Essential tremor K1 alpha-synuclein K1 plasma biomarker K1 diagnosis K1 Bioquímica K1 Biochemistry K1 Biología molecular K1 Molecular biology AB Background: Studies have revealed controversial results regarding the diagnostic accuracy of plasma α-synuclein levels in patients with Parkinson’s disease (PD). This study was aimed to analyze the diagnostic accuracy of plasma α-synuclein in PD versus healthy controls and patients with essential tremor (ET).Methods: In this cross-sectional study, we included de novo (n = 19) and advanced PD patients [OFF (n = 33), and On (n = 35) states], patients with ET (n = 19), and controls (n = 35). The total plasma α-synuclein levels were determined using an ELISA sandwich method. We performed adjusted multivariate regression analysis to estimate the association of α-synuclein levels with group conditions [controls, ET, and de novo, OFF and ON-PD]. We studied the diagnostic accuracy of plasma α-synuclein using the area under the curve (AUC).Results: The plasma α-synuclein levels were higher in controls compared to PD and ET (p < 0.0001), discriminating de novo PD from controls (AUC = 0.74, 95% CI 0.60–0.89), with a trend towards in advanced PD (OFF state) from ET (AUC = 0.69, 95% CI 0.53–0.84).Conclusions: This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET. PB Ubiquity Press YR 2021 FD 2021-05 LK http://hdl.handle.net/10259/5817 UL http://hdl.handle.net/10259/5817 LA eng NO Junta de Castilla y León is acknowledged for funding through the Biomedicine open project call (Ref. BIO/BU06/14) DS Repositorio Institucional de la Universidad de Burgos RD 28-mar-2024