RT info:eu-repo/semantics/article
T1 Can plasma α-Synuclein help us to differentiate parkinson’s disease from essential tremor?
A1 Albillos García, Silvia María
A1 Montero, Olimpio
A1 Calvo Meruelo, Sara
A1 Solano, Berta
A1 Trejo Gabriel y Galán, José Mª
A1 Cubo Delgado, Esther
K1 Parkinson’s disease
K1 Essential tremor
K1 alpha-synuclein
K1 plasma biomarker
K1 diagnosis
K1 Bioquímica
K1 Biochemistry
K1 Biología molecular
K1 Molecular biology
AB Background: Studies have revealed controversial results regarding the diagnostic accuracy of plasma α-synuclein levels in patients with Parkinson’s disease (PD). This study was aimed to analyze the diagnostic accuracy of plasma α-synuclein in PD versus healthy controls and patients with essential tremor (ET).Methods: In this cross-sectional study, we included de novo (n = 19) and advanced PD patients [OFF (n = 33), and On (n = 35) states], patients with ET (n = 19), and controls (n = 35). The total plasma α-synuclein levels were determined using an ELISA sandwich method. We performed adjusted multivariate regression analysis to estimate the association of α-synuclein levels with group conditions [controls, ET, and de novo, OFF and ON-PD]. We studied the diagnostic accuracy of plasma α-synuclein using the area under the curve (AUC).Results: The plasma α-synuclein levels were higher in controls compared to PD and ET (p < 0.0001), discriminating de novo PD from controls (AUC = 0.74, 95% CI 0.60–0.89), with a trend towards in advanced PD (OFF state) from ET (AUC = 0.69, 95% CI 0.53–0.84).Conclusions: This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET.
PB Ubiquity Press
YR 2021
FD 2021-05
LK http://hdl.handle.net/10259/5817
UL http://hdl.handle.net/10259/5817
LA eng
NO Junta de Castilla y León is acknowledged for funding through the Biomedicine open project call (Ref. BIO/BU06/14)
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024