RT info:eu-repo/semantics/article T1 In vitro safety evaluation of rare earth-lean alloys for permanent magnets manufacturing A1 Rumbo Lorenzo, Carlos A1 Cancho Espina, Cristina A1 Gassmann, Jürgen A1 Tosoni, Olivier A1 Barros García, Rocío A1 Martel Martín, Sonia A1 Tamayo Ramos, Juan Antonio K1 Materiales K1 Materials AB Due to their exceptional physico-chemical and magnetic characteristics, rare earth (RE) permanentmagnets are applied in multiple critical technologies. However, several environmental andeconomic difficulties arising from obtaining RE elements have prompted the search of alternativeswith acceptable magnetic properties but containing a lower percentage of these elements in theircomposition. The aim of this work was to perform a preliminary toxicological evaluation of three formsof newly developed RE-lean alloys (one NdFeTi and two NdFeSi alloys) applying different in vitroassays, using as a benchmark a commercial NdFeB alloy. Thus, the effects of the direct exposure topowder suspensions and to their derived leachates were analysed in two model organisms (the A549human cell line and the yeast Saccharomyces cerevisiae) applying both viability and oxidative stressassays. Moreover, the impact of the alloy leachates on the bioluminescence of Vibrio fischeri was alsoinvestigated. The obtained data showed that only the direct interaction of the alloys particulates withthe applied organisms resulted in harmful effects, having all the alloys a comparable toxicologicalpotential to that presented by the reference material in the conditions tested. Altogether, this studyprovides new insights about the safety of NdFeTi and NdFeSi alloys. PB Nature Research YR 2021 FD 2021-06 LK http://hdl.handle.net/10259/5845 UL http://hdl.handle.net/10259/5845 LA eng NO EU Horizon 2020 NOVAMAG project (NMBP 23-2015, Grant Agreement No. 686056) and from the Junta de Castilla y León and the European Social Fund-Youth European Initiative Grant UBU-15-A. DS Repositorio Institucional de la Universidad de Burgos RD 24-nov-2024