RT info:eu-repo/semantics/article
T1 UV/Vis absorption spectroelectrochemistry of folic acid
A1 Olmo Alonso, Fabiola
A1 Rodríguez Rubio, Andrea
A1 Colina Santamaría, Álvaro
A1 Heras Vidaurre, Aránzazu
K1 Vitamin B9
K1 Pharmaceutical drug
K1 Electrochemistry
K1 UV/Vis absorption spectroscopy
K1 Química analítica
K1 Chemistry, Analytic
AB UV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary informationthat is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallelconfiguration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistryhas been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowingus to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders ofmagnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. Thespectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interestingbecause of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results withvery good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorptionspectroelectrochemistry.
PB Springer
SN 1433-0768
YR 2021
FD 2021-08
LK http://hdl.handle.net/10259/6118
UL http://hdl.handle.net/10259/6118
LA eng
NO Ministerio de Economía y Competitividad (GrantCTQ2017-83935-R-AEI/FEDERUE), Junta de Castilla y León (GrantBU297P18), and Ministerio de Ciencia, Innovación y Universidades(Grant RED2018-102412-T). F.O. is grateful for the contract fundedby Junta de Castilla y León, the European Social Fund, and the YouthEmployment Initiative.
DS Repositorio Institucional de la Universidad de Burgos
RD 04-dic-2024