RT info:eu-repo/semantics/article T1 Spectroelectrochemical Determination of Isoprenaline in a Pharmaceutical Sample A1 Olmo Alonso, Fabiola A1 Garoz Ruiz, Jesús A1 Carazo, Julia A1 Colina Santamaría, Álvaro A1 Heras Vidaurre, Aránzazu K1 Spectroelectrochemistry K1 Electrochemistry K1 UV/Vis absorption K1 Drug analysis K1 Isoproterenol K1 Metabisulfite K1 Química analítica K1 Chemistry, Analytic AB UV/Vis absorption spectroelectrochemistry (SEC) is a multi-response technique that hasbeen commonly used for the characterization of materials and the study of reaction mechanisms.However, it has been scarcely used for quantitative purposes. SEC allows us to obtain two analyticalsignals simultaneously, yielding a dual sensor in just one experiment. In the last years, our grouphas developed new devices useful for analysis. In this work, a SEC device in parallel configuration,based on optical fibers fixed on screen-printed electrodes, was used to determine isoprenalinein a commercial drug, using both, the electrochemical and the spectroscopic signals. In thiscommercial drug, isoprenaline is accompanied in solution by other compounds. Among them issodium metabisulfite, an antioxidant that strongly interferes in the isoprenaline determination. Asimple pretreatment of the drug sample by bubbling wet-air allows us to avoid the interference ofmetabisulfite. Here, we demonstrate again the capabilities of UV/Vis absorption SEC as double sensorfor analysis and we propose a simple pretreatment to remove interfering compounds. PB MDPI SN 1424-8220 YR 2020 FD 2020-09 LK http://hdl.handle.net/10259/6121 UL http://hdl.handle.net/10259/6121 LA eng NO Ministerio de Economía y Competitividad (Grant CTQ2017-83935-R-AEI/FEDERUE), Junta de Castilla y León (Grant BU297P18), and Ministerio de Ciencia, Innovación y Universidades (Grant RED2018-102412-T). F.O. is grateful for the contract funded by Junta de Castilla y León, the European Social Fund and the Youth Employment Initiative. J.G.R. thanks Ministerio de Economía y Competitividad for his postdoctoral contract (Grant CTQ2017-83935-R AEI/FEDER, UE). DS Repositorio Institucional de la Universidad de Burgos RD 28-mar-2024