RT info:eu-repo/semantics/article T1 Screening the biological properties of transition metal carbamates reveals gold(I) and silver(I) complexes as potent cytotoxic and antimicrobial agents A1 Bresciani, Giulio A1 Busto Vázquez, Natalia A1 Ceccherini, Valentina A1 Bortoluzzi, Marco A1 Pampaloni, Guido A1 García Ruiz, Begoña A1 Marchetti, Fabio K1 Metals in medicine K1 Anticancer metal complexes K1 Transition metal complexes K1 Metal carbamates K1 Cytotoxicity K1 Antibacterial activity K1 Química inorgánica K1 Chemistry, Inorganic K1 Bioquímica K1 Biochemistry AB We report a screening study aimed to assess for the first time the air- and water-stability and the biological potential of simple metal-carbamates. These molecular metallic species are based on elements belonging to the groups 4–5, 7–9 and 11, and tin, and are easily available from inexpensive reagents. Complexes [Ag(O2CNEt2)] (13-Ag) and [Au(O2CNMe2)(PPh3)] (14-Au) resulted substantially stable in aqueous media and exhibited a potent in vitro cytotoxicity. Especially 13-Ag revealed a significant selectivity against the A549 lung adenocarcinoma and the A2780 ovarian cancer cell lines with respect to the noncancerous HEK293 cell line. Generation of ROS (reactive oxygen species) and mitochondrial membrane depolarization were recognized for 13-Ag and 14-Au; notwithstanding, the cell death mechanism is different in the two cases: apoptosis and cell cycle arrest in G0/G1 phase for 13-Ag; necroptosis and cell cycle arrest in S phase for 14-Au. Both 13-Ag and 14-Au are endowed with antibacterial activity, which is relatively stronger for 13-Ag towards Gram negative and for 14-Au towards Gram positive strains, respectively. PB Elsevier SN 0162-0134 YR 2022 FD 2022-02 LK http://hdl.handle.net/10259/6255 UL http://hdl.handle.net/10259/6255 LA eng NO La Caixa Foundation (LCF/PR/PR12/11070003), Consejería de Educación-Junta de Castilla y León-FEDER Funds (BU305P18), Ministerio de Ciencia, Innovación y Universidades (RTI2018-102040-B-100) and the University of Pisa (PRA_2020_39). DS Repositorio Institucional de la Universidad de Burgos RD 29-mar-2024