RT info:eu-repo/semantics/article
T1 Screening the biological properties of transition metal carbamates reveals gold(I) and silver(I) complexes as potent cytotoxic and antimicrobial agents
A1 Bresciani, Giulio
A1 Busto Vázquez, Natalia
A1 Ceccherini, Valentina
A1 Bortoluzzi, Marco
A1 Pampaloni, Guido
A1 García Ruiz, Begoña
A1 Marchetti, Fabio
K1 Metals in medicine
K1 Anticancer metal complexes
K1 Transition metal complexes
K1 Metal carbamates
K1 Cytotoxicity
K1 Antibacterial activity
K1 Química inorgánica
K1 Chemistry, Inorganic
K1 Bioquímica
K1 Biochemistry
AB We report a screening study aimed to assess for the first time the air- and water-stability and the biological potential of simple metal-carbamates. These molecular metallic species are based on elements belonging to the groups 4–5, 7–9 and 11, and tin, and are easily available from inexpensive reagents. Complexes [Ag(O2CNEt2)] (13-Ag) and [Au(O2CNMe2)(PPh3)] (14-Au) resulted substantially stable in aqueous media and exhibited a potent in vitro cytotoxicity. Especially 13-Ag revealed a significant selectivity against the A549 lung adenocarcinoma and the A2780 ovarian cancer cell lines with respect to the noncancerous HEK293 cell line. Generation of ROS (reactive oxygen species) and mitochondrial membrane depolarization were recognized for 13-Ag and 14-Au; notwithstanding, the cell death mechanism is different in the two cases: apoptosis and cell cycle arrest in G0/G1 phase for 13-Ag; necroptosis and cell cycle arrest in S phase for 14-Au. Both 13-Ag and 14-Au are endowed with antibacterial activity, which is relatively stronger for 13-Ag towards Gram negative and for 14-Au towards Gram positive strains, respectively.
PB Elsevier
SN 0162-0134
YR 2022
FD 2022-02
LK http://hdl.handle.net/10259/6255
UL http://hdl.handle.net/10259/6255
LA eng
NO La Caixa Foundation (LCF/PR/PR12/11070003), Consejería de Educación-Junta de Castilla y León-FEDER Funds (BU305P18), Ministerio de Ciencia, Innovación y Universidades (RTI2018-102040-B-100) and the University of Pisa (PRA_2020_39).
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024