RT info:eu-repo/semantics/article
T1 Monitoring of the evolution of human chronic wounds using a ninhydrin-based sensory polymer and a smartphone
A1 Guembe García, Marta
A1 Santaolalla García, Victoria
A1 Moradillo Renuncio, Natalia
A1 Ibeas Cortes, Saturnino
A1 Reglero Ruiz, José Antonio
A1 García García, Félix Clemente
A1 Pacheco Bonrostro, Joaquín
A1 Casado Yusta, Silvia
A1 García Pérez, José Miguel
A1 Vallejos Calzada, Saúl
K1 Monitoring human chronic wounds
K1 Polymer chemosensor
K1 Smartphone
K1 Química orgánica
K1 Chemistry, Organic
K1 Química física
K1 Chemistry, Physical and theoretical
K1 Química analítica
K1 Chemistry, Analytic
K1 Tecnología
K1 Technology
AB The healing processes in cutaneous wounds, i.e., chronic wounds, represent a health problem affecting 1–2 % of the population. The evaluation of these wounds is mainly based on subjective parameters, although there is a medical consensus on protease activity as the best marker for healing disorders. Here we show the correlation of the amino acid concentration on chronic wounds and with their evolution, and the development of a test kit to straightforward determining this evolution. Our test kit is a colorimetric sensory polymer film that change its colour upon contacting amino acids. The kit allows for the quantification of the overall amino acid concentration by simply analysing the colour definition parameters of the sensory film obtained from of a photograph taken with a smartphone. We analysed with the kit the amino acid concentration of human chronic wounds of 34 patients and we mathematically demonstrate that there is a correlation with the amino acid concentration, related with the protease activity, and the evolution of the wound’s diagnoses. This kit can help diagnosis of human chronic wounds, usually evaluated and treated along time by different physicians, or even by different medical teams, providing an analytical tool not subjected to subjective evaluation.
PB Elsevier
SN 0925-4005
YR 2021
FD 2021-05
LK http://hdl.handle.net/10259/7129
UL http://hdl.handle.net/10259/7129
LA eng
NO Spanish Ministerio de Economía, Industria y Competitividad (MAT2017-84501-R and ECO2016-76567-C4-2-R) and the Consejería de Educación, Junta de Castilla y León (BU306P18 and BU071G19
DS Repositorio Institucional de la Universidad de Burgos
RD 11-dic-2024