RT info:eu-repo/semantics/article
T1 Bacteriophages as Biotechnological Tools
A1 Alves Elois, Mariana
A1 Silva, Raphael da
A1 Pilati, Giulia
A1 Rodríguez Lázaro, David
A1 Fongaro, Gislaine
K1 Bacteriophages
K1 Applications
K1 Biotechnological
K1 Microbiología
K1 Microbiology
AB Bacteriophages are ubiquitous organisms that can be specific to one or multiple strainsof hosts, in addition to being the most abundant entities on the planet. It is estimated that theyexceed ten times the total number of bacteria. They are classified as temperate, which means thatphages can integrate their genome into the host genome, originating a prophage that replicateswith the host cell and may confer immunity against infection by the same type of phage; and lytics,those with greater biotechnological interest and are viruses that lyse the host cell at the end of itsreproductive cycle. When lysogenic, they are capable of disseminating bacterial antibiotic resistancegenes through horizontal gene transfer. When professionally lytic—that is, obligately lytic and notrecently descended from a temperate ancestor—they become allies in bacterial control in ecologicalimbalance scenarios; these viruses have a biofilm-reducing capacity. Phage therapy has also beenadvocated by the scientific community, given the uniqueness of issues related to the control ofmicroorganisms and biofilm production when compared to other commonly used techniques. Theadvantages of using bacteriophages appear as a viable and promising alternative. This review willprovide updates on the landscape of phage applications for the biocontrol of pathogens in industrialsettings and healthcare.
PB MDPI
YR 2023
FD 2023-01
LK http://hdl.handle.net/10259/7557
UL http://hdl.handle.net/10259/7557
LA eng
NO This study was funded by CNPQ and the Federal University of Santa Catarina, SIGPEX UFSC–201917940.
DS Repositorio Institucional de la Universidad de Burgos
RD 24-nov-2024