RT info:eu-repo/semantics/article T1 The Burden of Carbohydrates in Health and Disease A1 Clemente-Suárez, Vicente Javier A1 Mielgo Ayuso, Juan A1 Martín-Rodríguez, Alexandra A1 Ramos-Campo, Domingo Jesús A1 Redondo-Flórez, Laura A1 Tornero-Aguilera, José Francisco K1 Metabolic disease K1 Cancer K1 Gut microbiome K1 Asthma K1 Nutrition K1 Carbohydrates K1 Fisiología K1 Physiology K1 Medicina K1 Medicine K1 Salud K1 Health K1 Nutrición K1 Nutrition AB Foods high in carbohydrates are an important part of a healthy diet, since they providethe body with glucose to support bodily functions and physical activity. However, the abusiveconsumption of refined, simple, and low-quality carbohydrates has a direct implication on thephysical and mental pathophysiology. Then, carbohydrate consumption is postulated as a crucialfactor in the development of the main Western diseases of the 21st century. We conducted thisnarrative critical review using MedLine (Pubmed), Cochrane (Wiley), Embase, and CinAhl databaseswith the MeSH-compliant keywords: carbohydrates and evolution, development, phylogenetic,GUT, microbiota, stress, metabolic health, consumption behaviors, metabolic disease, cardiovasculardisease, mental disease, anxiety, depression, cancer, chronic kidney failure, allergies, and asthmain order to analyze the impact of carbohydrates on health. Evidence suggests that carbohydrates,especially fiber, are beneficial for the well-being and growth of gut microorganisms and consequentlyfor the host in this symbiotic relationship, producing microbial alterations a negative effect on mentalhealth and different organic systems. In addition, evidence suggests a negative impact of simplecarbohydrates and refined carbohydrates on mood categories, including alertness and tiredness,reinforcing a vicious circle. Regarding physical health, sugar intake can affect the development andprognosis of metabolic disease, as an uncontrolled intake of refined carbohydrates puts individualsat risk of developing metabolic syndrome and subsequently developing metabolic disease. PB MDPI YR 2022 FD 2022-09 LK http://hdl.handle.net/10259/7573 UL http://hdl.handle.net/10259/7573 LA eng DS Repositorio Institucional de la Universidad de Burgos RD 25-abr-2024