RT info:eu-repo/semantics/article T1 Accelerometer Cut-Points for Physical Activity Assessment in Adults with Mild to Moderate Huntington’s Disease: A Cross-Sectional Multicentre Study A1 Simón Vicente, Lucía A1 Rivadeneyra Posadas, Jéssica Jannett A1 Soto Célix, María . A1 Raya-González, Javier A1 Castillo, Daniel A1 Calvo Simal, Sara A1 Collazo Riobó, Carla A1 Rodríguez Fernández, Alejandro A1 Fahed, Vitoria S. A1 Mariscal, Natividad A1 García Bustillo, Álvaro A1 Aguado, Laura A1 Cubo Delgado, Esther K1 Accelerometry K1 Energy metabolism K1 Rehabilitation K1 Actigraphy K1 Calorimetry K1 Indirect K1 Salud K1 Health K1 Medicina K1 Medicine AB Accelerometers can estimate the intensity, frequency, and duration of physical activityin healthy adults. Although thresholds to distinguish varying levels of activity intensity using theActigraph wGT3X-B have been established for the general population, their accuracy for Huntington’sdisease (HD) is unknown. We aimed to define and cross-validate accelerometer cut-points for differentwalking speeds in adults with mild to moderate HD. A cross-sectional, multicentre, case-control,observational study was conducted with a convenience sample of 13 symptomatic ambulatory HDparticipants. The accelerometer was placed around the right hip, and a heart monitor was fittedaround the chest to monitor heart rate variability. Participants walked on a treadmill at three speedswith light, moderate and vigorous intensities. Correlation and receiver operation curve analyses wereperformed between the accelerometer magnitude vector with relative oxygen and heart rate. Optimalcut-points for walking speeds of 3.2 km/h were ≤2852; 5.2 km/h: >2852 to ≤4117, and in incrementsuntil their maximum velocity: >4117. Our results support the application of the disease-specificcut-points for quantifying physical activity in patients with mild to moderate HD and promotinghealthy lifestyle interventions. PB MDPI YR 2022 FD 2022-11 LK http://hdl.handle.net/10259/7574 UL http://hdl.handle.net/10259/7574 LA eng NO The project leading to these results has received funding from “La Caixa” Foundation (ID100010434), under agreement FUI1-PI008. DS Repositorio Institucional de la Universidad de Burgos RD 04-dic-2024