RT info:eu-repo/semantics/article T1 6-Week Supplementation with Tribulus terrestris L. to Trained Male CrossFit® Athletes on Muscle, Inflammation, and Antioxidant Biomarkers: A Randomized, Single-Blind, Placebo-Controlled Trial A1 Fernández-Lázaro, Diego A1 Seco-Calvo, Jesús A1 Pascual-Fernández, Jorge A1 Domínguez-Ortega, Carlos A1 Valle Soto, Miguel del A1 Mielgo Ayuso, Juan K1 Tribulus terrestris L. K1 Herbal supplementation K1 Crossfit K1 Muscle damage K1 Inflammation response K1 Exercise-induced oxidative stress K1 Fisiología K1 Physiology AB Tribulus terrestris L. (TT) ingredients have anti-inflammatory and antioxidant activities,but their effects on exercise-induced muscle damage (EIMD) in trained athletes are uncertain. Thepurpose of this single-blind placebo-controlled trial, in accordance with CONSORT guidelines,was to examine the effect of 6 weeks of TT supplementation on muscle metabolism, inflammationbiomarkers, and oxidant status. Thirty trained male CrossFit® athletes were randomly assigned to besupplemented with 770 mg/day of TT (intervention group (IG)) or receive a placebo daily (controlgroup (CG)) for 6 weeks. Muscle damage enzymes, inflammation biomarkers, and Total AntioxidantStatus (TAS) were assessed at baseline (T1), 21 days after baseline (T2), and after 42 days (T3). Grace, aWorkout of the Day, was measured in T1 and T3. Statistical significance (p < 0.05) was found betweenIG and CG in Lactate Dehydrogenase (LDH), C-reactive protein (CRP), and TAS levels at the end ofthe follow-up. Furthermore, TAS levels were significantly (p < 0.05) lower at T2 and T3 relative tobaseline in the IG, also LDH and CRP increased significantly (p < 0.05) at T2 and T3 relative to baselinein the CG. No significant (p > 0.05) decreases in muscle damage or inflammation biomarkers wereobserved, although a slight downward trend was observed after 6 weeks for supplemented athletes.TT supplementation could attenuate the CrossFit® training program-induced oxidative stress, muscledamage, and inflammation which could be due to the natural antioxidant and anti-inflammatoryproperties of TT. PB MDPI YR 2022 FD 2022-12 LK http://hdl.handle.net/10259/7578 UL http://hdl.handle.net/10259/7578 LA eng DS Repositorio Institucional de la Universidad de Burgos RD 25-abr-2024