RT info:eu-repo/semantics/article
T1 25-Hydroxyvitamin D Serum Levels Linked to Single Nucleotide Polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in Skeletal Muscle Aging in Institutionalized Elderly Men Not Supplemented with Vitamin D
A1 Fernández-Lázaro, Diego
A1 García Hernández, Juan Luis
A1 Lumbreras, Eva
A1 Mielgo Ayuso, Juan
A1 Seco-Calvo, Jesús
K1 Elderly
K1 Aging
K1 Sarcopenia
K1 25-OH vitamin D
K1 Deficiency
K1 Genetics
K1 CYP2R1
K1 GC
K1 VDR
K1 Fisiología
K1 Physiology
AB Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results inan involution of muscle function and strength. Vitamin D deficiency is a common health problemworldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders.The aim of this study was to evaluate the impact and presence of a possible linkage between SingleNucleotide Polymorphisms (SNPs) CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs2228570),serum 25-OH/D concentrations and the link with the degree of sarcopenia in 19 institutionalizedelderly men not supplemented with vitamin D. Levels of 25-OH vitamin D were quantified witha commercial enzyme-linked immunosorbent assay kit and 3 SNPs were genotyped with KASParassays. Significant differences in 25-OH/D concentration were determined between the bi-alleliccombinations of rs228679 and rs228570. We detected statistically significant weak positive correlationsbetween the AA (rs10741657 and rs228570) and TT (rs228679) and alleles and 25-OH/D and theprobability of having higher 25-OH/D concentrations was 2- to 3-fold higher. However, the GGalleles of the 3 SNPs showed that the probability of having optimal 25-0H/D concentrations decreasesby 32% for rs10741657, 38% for rs228679, and 74% for rs228570, showing a strong negative correlationbetween the degree of sarcopenia and 25-OH/D levels. Allelic variations in CYP2R1 (rs10741657),GC (rs2282679), and VDR (rs10741657) affect vitamin D levels and decisively influence the degree ofsarcopenia in institutionalized elderly people.
PB MDPI
YR 2022
FD 2022-10
LK http://hdl.handle.net/10259/7579
UL http://hdl.handle.net/10259/7579
LA eng
NO This research has been funded by the Chair of Knowledge and Innovation “Caja Rural de Soria” University of Valladolid Campus de Soria, Soria (Spain) in the call for funding research projects with project number SO-1-2020. D.F.-L. and J.M.-A. were members of the research team.
DS Repositorio Institucional de la Universidad de Burgos
RD 11-dic-2024