RT info:eu-repo/semantics/article
T1 Effects of Citrulline Supplementation on Different Aerobic Exercise Performance Outcomes: A Systematic Review and Meta-Analysis
A1 Viribay, Aitor
A1 Fernández-Landa, Julen
A1 Castañeda-Babarro, Arkaitz
A1 Collado, Pilar S.
A1 Fernández-Lázaro, Diego
A1 Mielgo Ayuso, Juan
K1 Citrulline
K1 Ergogenic aids
K1 Physical performance
K1 Nitric oxide
K1 Aerobic
K1 Endurance
K1 Fisiología
K1 Physiology
AB Supplementation with Citrulline (Cit) has been shown to have a positive impact on aerobicexercise performance and related outcomes such as lactate, oxygen uptake (VO2) kinetics, and the rateof perceived exertion (RPE), probably due to its relationship to endogenous nitric oxide production.However, current research has shown this to be controversial. The main objective of this systematicreview and meta-analysis was to analyze and assess the effects of Cit supplementation on aerobicexercise performance and related outcomes, as well as to show the most suitable doses and timingof ingestion. A structured literature search was carried out by the PRISMA® (Preferred ReportingItems for Systematic Reviews and Meta-Analyses) and PICOS guidelines in the following databases:Pubmed/Medline, Scopus, and Web of Science (WOS). A total of 10 studies were included in theanalysis, all of which exclusively compared the effects of Cit supplementation with those of a placebogroup on aerobic performance, lactate, VO2, and the RPE. Those articles that used other supplementsand measured other outcomes were excluded. The meta-analysis was carried out using Hedges’ grandom effects model and pooled standardized mean differences (SMD). The results showed nopositive effects of Cit supplementation on aerobic performance (pooled SMD = 0.15; 95% CI (−0.02 to0.32); I2, 0%; p = 0.08), the RPE (pooled SMD = −0.03; 95% CI (−0.43 to 0.38); I2, 49%; p = 0.9), VO2kinetics (pooled SMD = 0.01; 95% CI (−0.16 to 0.17); I2, 0%; p = 0.94), and lactate (pooled SMD = 0.25;95% CI (−0.10 to 0.59); I2, 0%; p = 0.16). In conclusion, Cit supplementation did not prove to haveany benefits for aerobic exercise performance and related outcomes. Where chronic protocols seemedto show a positive tendency, more studies in the field are needed to better understand the effects.
PB MDPI
YR 2022
FD 2022-08
LK http://hdl.handle.net/10259/7580
UL http://hdl.handle.net/10259/7580
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 04-dic-2024