RT info:eu-repo/semantics/article
T1 Beneficial Effects of Olive Oil Enriched with Lycopene on the Plasma Antioxidant and Anti-Inflammatory Profile of Hypercholesterolemic Patients
A1 Martínez Álvarez, Jesús Román
A1 López Jaen, Ana Belén
A1 Cavia Saiz, Mónica
A1 Muñiz Rodríguez, Pilar
A1 Valls-Belles, Victoria
K1 Lycopene
K1 Olive oil
K1 CRP
K1 Cholesterol
K1 Cytokines
K1 Antioxidant capacity
K1 Oxidative stress biomarkers
K1 Alimentos
K1 Food
K1 Biología molecular
K1 Molecular biology
K1 Bioquímica
K1 Biochemistry
AB Olive oil and lycopene are foods that have potent antioxidant activity. The objective wasto determine the effects of consumption of olive oil enriched with lycopene on oxidative stressbiomarkers in hypercholesterolemic subjects. We examined the effects of oil enriched with lycopeneextract daily intake during 1 month on plasma antioxidant capacity, lipids profile (triacylgycerols, totalcholesterol, cHDL; cLDL, ox-LDL), biomarkers of oxidative stress, and inflammatory markers relatedwith atherosclerosis risk (C-reactive protein (CRP), IL-6; sDC4L) in subjects hypercholesteremics(cholesterol > 220 mg/dL). In the group consuming olive oil-lycopene, significant increases (p < 0.05)in the levels of plasma lycopene concentration (0.146 ± 0.03 versus 0.202 ± 0.04 (µmol/L)), α-carotene(0.166 ± 0.064 versus 0.238 ± 0.07) and in β-carotene (0.493 ± 0.187 versus 0.713 ± 0.221) wereobserved. These results are linked with the increases of plasma antioxidants and decreases biomarkersof oxidative stress (carbonyl groups, malondialdehyde and 8-hydroxy-deoxiguanosine) observedin hypercholesterolemic group. In relation to lipid profile, a significant decrease was observedin the levels of ox-LDL (781 ± 302 versus 494 ± 200), remaining unchanged the levels of TG,cholesterol, HDL and LDL-c. Regarding inflammatory biomarkers, the levels of CRP and IL-6decreased significantly. The positive results obtained in this study support the use of olive oilenriched with lycopene to reduce the risk of coronary disease.
PB MDPI
YR 2023
FD 2023-07
LK http://hdl.handle.net/10259/8050
UL http://hdl.handle.net/10259/8050
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 25-dic-2024