RT info:eu-repo/semantics/article
T1 Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth
A1 Cavia Saiz, Mónica
A1 Arnaez, Juan
A1 Cilla, Amaia
A1 Puente, Laura
A1 García-Miralles, Laura C.
A1 Muñiz Rodríguez, Pilar
K1 Oxidative stress
K1 Infant
K1 Birth
K1 Cord blood
K1 Glutathione
K1 Malondialdehyde
K1 Carbonyl
K1 Creatinine
K1 Alimentos
K1 Food
K1 Biología molecular
K1 Molecular biology
K1 Bioquímica
K1 Biochemistry
AB The clinical relevance of stress biomarkers in newborns is well established. Currently,oxidative stress (OS) parameters are seen to play an important role in neonatal resuscitation guidelines,and a link has been observed between the amount of oxygen delivered and the level of OS and thedevelopment of various pathologies. The aim of the current study was to investigate changes inneonatal plasma and urine OS status during the first hours after birth. A lower antioxidant capacity(TAC) and higher levels of malondialdehyde in blood were observed in newborns at the time ofbirth compared with results 48 h postnatally. The urine revealed a significant and progressiveincrease in TAC and creatinine during the first 36 h of life, with a progressive decline thereafter.Meanwhile, malondialdehyde in urine samples showed no significant differences over time. Overall,the correlation between blood and urine parameters was poor, except for the relationship betweenumbilical vein glutathione reduced/oxidized ratio and urine malondialdehyde (r = 0.7; p = 0.004)and between TAC in the umbilical artery and urine (r = −0.547; p = 0.013). The biomarkers evaluatedin this study could be established as reference values for neonatal OS.
PB MDPI
YR 2023
FD 2023-06
LK http://hdl.handle.net/10259/8051
UL http://hdl.handle.net/10259/8051
LA eng
NO This research was funded by Fundación Burgos por la Investigación de la Salud (grant number 1088) and Gerencia Regional de Castilla y Leon (grant number GRS 1773/A/18).
DS Repositorio Institucional de la Universidad de Burgos
RD 25-dic-2024