RT info:eu-repo/semantics/article
T1 Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy
A1 Caño Espinel, Manuela del
A1 Acebes, Judith R.
A1 Sánchez, Diego
A1 Ganfornina, María D.
K1 Autophagy
K1 Neurodegeneration
K1 Neuroprotection
K1 Polyubiquitinated protein clearance
K1 Drosophila
K1 GLaz
K1 NLaz
K1 ApoD
K1 GstS1
K1 Atg1/ULK1
K1 Atg4a
K1 Atg8a/LC3
K1 p62
K1 Neurología
K1 Neurology
K1 Medicina
K1 Medicine
AB A diverse set of neurodegenerative disorders are caused by abnormal extensions of polyglutamine (poly-Q) stretches in various, functionally unrelated proteins. A common feature of these diseases is altered proteostasis. Autophagy induction is part of the endogenous response to poly-Q protein expression. However, if autophagy is not resolved properly, clearance of toxic proteins or aggregates cannot occur effectively. Likewise, excessive autophagy induction can cause autophagic stress and neurodegeneration. The Lipocalins ApoD, Glial Lazarillo (GLaz) and Neural Lazarillo (NLaz) are neuroprotectors upon oxidative stress or aging. In this work we test whether these Lipocalins also protect against poly-Q-triggered deterioration of protein quality control systems.
PB BMC
YR 2015
FD 2015
LK http://hdl.handle.net/10259/8207
UL http://hdl.handle.net/10259/8207
LA eng
NO This work was supported by grants to MDG and DS: Junta de Castilla y León (JCyL) grant VA180A11-2, and Ministerio de Ciencia e Innovación (MICINN) grants BFU2008-01170 and BFU2011-23978. MdC-E was supported by a University of Valladolid, predoctoral fellowship.
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024