RT info:eu-repo/semantics/article
T1 Incorporating Cellular Stochasticity in Solid–Fluid Mixture Biofilm Models
A1 Carpio, Ana
A1 Cebrián de Barrio, Elena
K1 Biofilm
K1 Cellular activity
K1 Solid–fluid mixture
K1 Thin film
K1 Von Karman plate
K1 Dynamic energy budget
K1 Osmotic spread
K1 Wrinkle formation
K1 Cell differentiation
K1 Matemáticas
K1 Mathematics
K1 Microbiología
K1 Microbiology
AB The dynamics of cellular aggregates is driven by the interplay of mechanochemical processes and cellular activity. Although deterministic models may capture mechanical features, local chemical fluctuations trigger random cell responses, which determine the overall evolution. Incorporating stochastic cellular behavior in macroscopic models of biological media is a challenging task. Herein, we propose hybrid models for bacterial biofilm growth, which couple a two phase solid/fluid mixture description of mechanical and chemical fields with a dynamic energy budget-based cellular automata treatment of bacterial activity. Thin film and plate approximations for the relevant interfaces allow us to obtain numerical solutions exhibiting behaviors observed in experiments, such as accelerated spread due to water intake from the environment, wrinkle formation, undulated contour development, and the appearance of inhomogeneous distributions of differentiated bacteria performing varied tasks.
PB MDPI
SN 1099-4300
YR 2020
FD 2020
LK http://hdl.handle.net/10259/8252
UL http://hdl.handle.net/10259/8252
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 04-dic-2024