RT info:eu-repo/semantics/article
T1 Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
A1 Albillos García, Silvia María
A1 Montero, Olimpio
A1 Calvo Simal, Sara
A1 Solano, Berta
A1 Trejo Gabriel y Galán, José Mª
A1 Cubo Delgado, Esther
K1 Parkinson’s disease
K1 Essential tremor
K1 Plasma biomarkers
K1 Bilirubin
K1 Acyl-carnitines
K1 Tyramine
K1 Tetrahydro-21-deoxycortisol
K1 Motor skills disorders
K1 Química
K1 Chemistry
K1 Bioquímica
K1 Biochemistry
K1 Biotecnología
K1 Biotechnology
K1 Neurología
K1 Neurology
AB Background and purposeGiven the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson's disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their association with motor and non-motor symptoms (NMS) in patients with PD, and to determine differences between de novo PD compared to moderate-advanced PD vs. controls and patients with ET.MethodsPlasma samples were collected from 137 subjects including 35 age matched controls, 29 NOVO-PD, 35 PD and 38 ET patients. PD severity, motor and NMS including cognitive function were assessed using the UPDRS, NMS and PD cognitive rating scales, respectively. Metabolomics analysis was performed by UPLC-ESI-QToF-MS followed by unsupervised multivariate statistics. The area under the curve of the biomarkers according to distribution of their concentrations and the diagnosis of PD (NOVO-PD, advanced PD) vs ET and healthy controls was used as a measurement of diagnostic ability.ResultsSeveral acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol (THS) presented good predictive accuracy (AUC higher than 0.8) for differentiating de novo PD and advanced PD from controls and ET, suggesting an alteration in the lipid oxidation pathway. In multivariate regression analysis, metabolite levels were not significantly associated with motor and NMS severity in PD.ConclusionsDiverse acyl-carnitines, bilirubin, tyramine and some adrenal gland derived metabolites are suggested as potential biomarkers able to distinguish between PD from controls and ET.
PB Elsevier
SN 1353-8020
YR 2021
FD 2021
LK http://hdl.handle.net/10259/8307
UL http://hdl.handle.net/10259/8307
LA eng
NO This work was supported by Junta de Castilla y León (BIO/BU06/14).
DS Repositorio Institucional de la Universidad de Burgos
RD 23-nov-2024