RT info:eu-repo/semantics/article
T1 Depression as a Risk Factor for Alzheimer’s Disease: A Systematic Review of Longitudinal Meta-Analyses
A1 Sáiz Vázquez, Olalla
A1 Gracia García, Patricia
A1 Ubillos Landa, Silvia
A1 Puente Martínez, Alicia
A1 Casado Yusta, Silvia
A1 Olaya, Beatriz
A1 Santabárbara, Javier
K1 Depression
K1 Alzheimer's disease
K1 Clinical and symptomatic criteria
K1 Meta-meta-analysis
K1 Economía
K1 Economy
K1 Medicina
K1 Medicine
K1 Salud
K1 Health
K1 Psicología
K1 Psychology
AB Alzheimer’s disease (AD) is the most frequent cause of dementia, linked to morbidityand mortality among elderly patients. Recently, several clinical studies suggested that depressionis a potential risk factor for cognitive decline and AD. A review of meta-analyses was performed,calculating pooled odds ratios to estimate the risk of AD in people with a prior diagnosis (or clinicallysignificant symptoms) of depression. A total of six meta-analyses which represented 28 individualstudies were analyzed. A significant association between depression and AD was found (OR = 1.54,95% CI [1.02–2.31]; p = 0.038). The results showed that heterogeneity across studies was substantial.We found a significant positive effect size for clinical measures of depression, but not for symptomaticrating scales, in the association of depression with risk of AD. The type of rating scale used to assessdepression and the cut-off criteria selected also moderated the relationship between depression andAD risk. We found that studies that used clinically significant criteria for diagnosis of depression hadmore consistent and significant results than studies that used symptomatic scales.
PB MDPI
YR 2021
FD 2021-04
LK http://hdl.handle.net/10259/8410
UL http://hdl.handle.net/10259/8410
LA eng
NO This study was supported by Grants from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness, Madrid, Spain (grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, 12/02254, 16/00896, PI/19/01874, G03/128) and from the Fondo Europeo de Desarrollo Regional (FEDER) of the European Union “Una manera de hacer Europa” (Project number PI16/00896) and Gobierno de Aragón (grant B15_17R). BO’s work is supported by the Miguel Servet program (CP20/00040), funded by the Instituto de Salud Carlos III and co-funded by the European Union (ERDF/ESF, “Investing in your future”). This study was partially supported by FEDER funds and the Spanish Ministry of Economy and Competitiveness (Projects ECO2016-76567-C4-2-R and PID2019-104263RB-C44), the Regional Government of “Castilla y León”, Spain (Project BU329U14 and BU071G19), the Regional Government of “Castilla y León”, and FEDER funds (Project BU062U16).
DS Repositorio Institucional de la Universidad de Burgos
RD 09-may-2024