RT info:eu-repo/semantics/article
T1 Formulation and evaluation of anion transporters in nanostructured lipid carriers
A1 Alonso Carrillo, Daniel
A1 Carreira Barral, Israel
A1 Mielczarek, Marcin
A1 Sancho Medina, Andrea
A1 Herran, Enara
A1 Vairo, Claudia
A1 Pozo, Ángel del
A1 Luzuriaga, Iris
A1 Lazcanoiturburu, Nerea
A1 Ibarrola, Oihane
A1 Ponce, Sara
A1 Villar Vidal, María
A1 García Valverde, María
A1 Quesada Pato, Roberto
K1 Química orgánica
K1 Chemistry, Organic
K1 Bioquímica
K1 Biochemistry
AB Six novel click-tambjamines (1–6) bearing an alkyl chain of varying length linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport activity both when free (i.e., not encapsulated) and nanoformulated. Nanostructured lipid carriers (NLCs) are an example of drug delivery systems (DDSs) that stand out because of their versatility. In this work we show that NLCs can be used to efficiently formulate highly lipophilic anionophores and experiments conducted in model liposomes reveal that these formulations are adequate to deliver anionophores without compromising their transport activity. This result paves the way to facilitate the study of highly lipophilic anionophores and their potential use as future drugs.
PB Royal Society of Chemistry
SN 1477-0520
YR 2023
FD 2023-08
LK http://hdl.handle.net/10259/8609
UL http://hdl.handle.net/10259/8609
LA eng
NO This research has been financially supported by Consejería de Educación de la Junta de Castilla y León and European Regional Development Fund (ERDF) (project BU067P20), Ministerio de Ciencia e Innovación (project PID2020-117610RB-I00), Gobierno Vasco (Elkartek program 2021 KK-2021/00052), and Alava Innova program 2021 (INNOAS-2021/00003) of the Provincial Council of Alava. D. A.-C. and I. C.-B. thank Consejería de Educación de la Junta de Castilla y León, ERDF and European Social Fund (ESF) for their pre-doctoral and post-doctoral contracts, respectively.
DS Repositorio Institucional de la Universidad de Burgos
RD 11-dic-2024