RT info:eu-repo/semantics/article
T1 Transcranial direct-current stimulation (tDCS) improves detection of simple bright stimuli by amblyopic Long Evans rats in the SLAG task and produces an increase of parvoalbumin labelled cells in visual cortices
A1 Castaño Castaño, Sergio
A1 Martínez Navarrete, Gema
A1 Morales Navas, Miguel
A1 Fernández Jover, Eduardo
A1 Sánchez Santed, Fernando
A1 Nieto Escámez, Francisco A.
K1 Amblyopia
K1 tDCS
K1 GABA
K1 Parvoalbumin
K1 SLAG
K1 Salud
K1 Health
K1 Ensayos (Tecnología)
K1 Testing
K1 Fisiología
K1 Physiology
K1 Biología molecular
K1 Molecular biology
AB In this work visual functional improvement of amblyopic Long Evans rats treated with tDCS has been assessedusing the “slow angled-descent forepaw grasping” (SLAG) test. This test is based on an innate response that doesnot requires any memory-learning component and has been used before for measuring visual function in rodents.The results obtained show that this procedure is useful to assess monocular but not binocular deficits, as controlsand amblyopic animals showed significant differences during monocular but not during binocular assessment.On the other hand, parvoalbumin labelling was analysed in three areas of the visual cortex (V1M, V1B and V2L)before and after tDCS treatment. No changes in labelling were observed after monocular deprivation. However,tDCS treatment significantly improved vision through the amblyopic eye, and a significant increase of parvoalbumin-positive cells was observed in the three areas, both in the stimulated hemisphere but also in the nonstimulated hemisphere. This effect occurred both in control and amblyopic animals. Thus, tDCS induced changesare similar in controls and amblyopic animals, although only the last one showed a functional improvement.
PB Elsevier
SN 0006-8993
YR 2019
FD 2019-02
LK http://hdl.handle.net/10259/8631
UL http://hdl.handle.net/10259/8631
LA eng
NO This research was supported by research grants PS09-01163, from FIS, and PSI2014-55785-C2-1-R, from MINECO and EU FEDER funds.
DS Repositorio Institucional de la Universidad de Burgos
RD 14-may-2024