RT info:eu-repo/semantics/article
T1 Medium and long-term effects of low doses of Chlorpyrifos during the postnatal, preweaning developmental stage on sociability, dominance, gut microbiota and plasma metabolites
A1 Pérez Fernández, Cristian
A1 Morales Navas, Miguel
A1 Aguilera Sáez, Luis Manuel
A1 Abreu, Ana Cristina
A1 Guardia Escote, Laia
A1 Fernández, Ignacio
A1 Garrido Cárdenas, José Antonio
A1 Colomina, María Teresa
A1 Giménez, Estela
A1 Sánchez Santed, Fernando
K1 Chlorpyrifos
K1 Development
K1 ASD
K1 Sociability
K1 Dominance
K1 Gut microbiota
K1 Metabolomics
K1 Evidence of approval (animals)
K1 Fisiología
K1 Psychology
K1 Biología molecular
K1 Molecular biology
AB Autism spectrum disorder (ASD) is a complex neurodevelopmental pathology characterized by altered verbalizations, reduced social interaction behavior, and stereotypies. Environmental factors have been associated withits development. Some researchers have focused on pesticide exposure. Chlorpyrifos (CPF) is the most usedOrganophosphate. Previous developmental studies with CPF showed decreased, enhanced or no effect on socialoutcomes eminently in mice. The study of CPF exposure during preweaning stages on social behavior is sparse inmice and non-existent in rats. d stressors could be at the basis of ASD development, and around postnatal day 10in the rat is equivalent to the human birthday in neurodevelopmental terms. We explored the effects of exposureto low doses (1mg/kg/mL/day) of CPF during this stage regarding: sociability, dominance gut microbiome andplasma metabolomic profile, since alterations in these systems have also been linked to ASD. There was a modestinfluence of CPF on social behavior in adulthood, with null effects during adolescence. Dominance and hierarchical status were not affected by exposure. Dominance status explained the significant reduction in reactionto social novelty observed on the sociability test. CPF induced a significant gut microbiome dysbiosis andtriggered a hyperlipidemic, hypoglycemic/hypogluconeogenesis and a general altered cell energy production infemales. These behavioral results in rats extend and complement previous studies with mice and show novelinfluences on gut metagenomics and plasma lipid profile and metabolomics, but do not stablish a relation between the exposure to CPF and the ASD phenotype. The effects of dominance status on reaction to social noveltyhave an important methodological meaning for future research on sociability.
PB Elsevier
SN 0013-9351
YR 2020
FD 2020-05
LK http://hdl.handle.net/10259/8633
UL http://hdl.handle.net/10259/8633
LA eng
NO This study was supported by two grants from the Ministerio de Economía y Competitividad, Spanish Government and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER). Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER and PSI2017-86847-C2-2-R.
DS Repositorio Institucional de la Universidad de Burgos
RD 14-may-2024