RT info:eu-repo/semantics/article
T1 Postnatal exposure to low doses of Chlorpyrifos induces long-term effects on 5C-SRTT learning and performance, cholinergic and GABAergic systems and BDNF expression
A1 Pérez Fernández, Cristian
A1 Morales Navas, Miguel
A1 Guardia Escote, Laia
A1 Colomina, María Teresa
A1 Giménez, Estela
A1 Sánchez Santed, Fernando
K1 Chlorpyrifos
K1 Locomotor activity
K1 Learning
K1 Attention
K1 Inhibitory control
K1 Brain-derived neurotrophic factor
K1 Fisiología
K1 Physiology
K1 Biología molecular
K1 Molecular biology
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
AB Alterations in attention and inhibitory control are common features in several neurological disorders.Environmental factors such as exposure to pesticides have been linked to their appearance. Chlorpyrifos (CPF) isone of the most widely used organophosphate compounds in the world. CPF exposure during development seemsto be critical for later behavioral and molecular disruptions during adult ages, although this depends on thespecific period of development, where the preweaning period is one of the least studied. Despite the abundantempirical work made in the last decades on developmental CPF exposure, the systematic study of this on attention is sparse, and nonexistent concerning inhibitory control, without a single study on preweaning developmental stages. The present research explored the effects of the exposure to low doses of CPF that do not elicit asignificant inhibition of the Cholinesterases during this developmental period on rats' behavior in the five-choiceserial reaction time task. Behavioral manipulations (inter-trial interval and stimulus duration), pharmacologicalmanipulations (cholinergic and GABAergic drugs) and brain gene expression analyses were also conducted.Exposure to CPF decreased the locomotor activity and enhanced the learning profile of the female rats, increasedthe impulsive rates, unmasked by a longer inter-trial interval, hypo-sensitized the cholinergic system and downregulated the mRNA expression levels of the brain-derived neurotrophic factor in the dorsal striatum of the malerats. This happened without significant inhibition of the brain Acetylcholinesterase. All this new informationcorroborates that the exposure to a common pesticide at low doses during a key, but under-explored developmental period importantly affects different behaviors, neurotransmitter systems, and molecules that are alteredin the main neurological disorders observed nowadays.
PB Elsevier
SN 0014-4886
YR 2020
FD 2020-08
LK http://hdl.handle.net/10259/8634
UL http://hdl.handle.net/10259/8634
LA eng
NO The present study was supported by two grants from the Ministerio de Economía y Competitividad, Spanish Government and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER). Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER and PSI2017-86847-C2-2-R.
DS Repositorio Institucional de la Universidad de Burgos
RD 13-may-2024