RT info:eu-repo/semantics/article
T1 Transcranial direct current stimulation improves visual acuity in amblyopic Long-Evans rats
A1 Castaño Castaño, Sergio
A1 Garcia-Moll, A.
A1 Morales Navas, Miguel
A1 Fernández Jover, Eduardo
A1 Sánchez Santed, Fernando
A1 Nieto Escámez, Francisco A.
K1 Visual deprivation
K1 Optomotor reflex
K1 Visual acuity
K1 Amblyopia
K1 tDCS
K1 Fisiología
K1 Physiology
K1 Biología molecular
K1 Molecular biology
K1 Salud
K1 Health
K1 Medicina
K1 Medicine
AB Transcranial direct current stimulation (tDCS) has proved to increase brain cortex plasticity and different models of brain damage. In this work, we have analyzed the effects of tDCS in an experimental model of amblyopia using Long-Evans rats. Animals were monocularly deprived between 12 and 75 postnatal days and visual cortex contralateral to the deprived eye was stimulated using anodal tDCS during 8 days (20 min/day). The effects of tDCS treatment on the visual function were evaluated by using the optomotor reflex of the animals as a measure of visual acuity. Results obtained indicate that monocular occlusion during the critical period lead to a reduction of visual acuity in monocular and binocular conditions. Stimulation with anodal tDCS produced a nearly full recovery in visual acuity of amblyopic animals. However, same stimulation protocol in healthy control animals produced a decrease of binocular visual acuity. These data indicate that tDCS can reverse the effects of monocular deprivation on visual acuity, although it is essential to use this technique in a controlled way due to the possible adverse effects on healthy individuals.
PB Elsevier
SN 0006-8993
YR 2017
FD 2017-02
LK http://hdl.handle.net/10259/8654
UL http://hdl.handle.net/10259/8654
LA eng
NO This research was supported by research Grants PS09-01163 from Fondo de Investigación en Salud (FIS), and PSI2014-55785-C2-1-R from MINECO and EU FEDER funds. We want to thank Prof. Antonio Fimia from University Miguel Hernández for his advice and helpful commentaries about the visual acuity assessment parameters and analysis procedure in Argos.
DS Repositorio Institucional de la Universidad de Burgos
RD 10-may-2024