RT info:eu-repo/semantics/article
T1 Blood pressure and Alzheimer's disease: A review of meta-analysis
A1 Sáiz Vázquez, Olalla
A1 Puente Martínez, Alicia
A1 Pacheco Bonrostro, Joaquín
A1 Ubillos Landa, Silvia
K1 Alzheimer's disease
K1 Blood pressure
K1 Systo-diastolic hypertension
K1 Risk factor
K1 Meta-analysis
K1 Medicina
K1 Medicine
K1 Salud
K1 Health
AB Background: Alzheimer's disease (AD) is a neurological disorder of unknown cause, resulting in the death of brain cells. Identifying some of the modifiable risk factors for AD could be crucial for primary prevention and could lead to a reduction in the incidence of AD.Objective: This study aimed to perform a meta-meta-analysis of studies in order to assess the effect of blood pressure (BP) on the diagnosis of AD.Method: The search was restricted to meta-analyses assessing high systolic BP (SBP) and diastolic BP (DBP) and AD. We applied the PRISMA guidelines.Results: A total of 214 studies were identified from major databases. Finally, five meta-analyses (52 studies) were analyzed in this review. Results confirm that high SBP is associated with AD. The exploration of parameters (sex, age, study design, region, and BP measurements) shows that only region significantly moderates the relationship between BP and AD. Asian people are those whose SBP levels >140 mmHg are associated with AD. BP is associated with AD in both people aged ≤65 years and those aged ≥65 years and in cross-sectional and longitudinal studies. In the case of DBP, only women are at a higher risk of AD, particularly when its levels are >90.Conclusion: SBP is associated with both cerebrovascular disease and AD. Therefore, future studies should use other uncontrolled factors, such as cardiovascular diseases, diabetes, and stroke, to explain the relationship between SBP and AD.
PB Frontiers Media
YR 2023
FD 2023-01
LK http://hdl.handle.net/10259/8703
UL http://hdl.handle.net/10259/8703
LA eng
NO This study was partially funded by grant Y133GI awarded by the University of Burgos (Spain) to the Social Inclusion and Quality of Life (SIQoL) research group. This work was partially supported by FEDER funds and the Spanish State Research Agency (Projects PID2019-104263RB-C44 and PDC2021-121021-C22) and the Regional Government of “Castilla y León” and FEDER funds (Project BU056P20).
DS Repositorio Institucional de la Universidad de Burgos
RD 09-may-2024