RT info:eu-repo/semantics/article
T1 Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease
A1 Santos García, Diego
A1 Suárez Castro, Ester
A1 Deus-Fonticoba, Teresa de
A1 Feal Panceiras, M. J.
A1 Muñoz Enríquez, J. G.
A1 Paz González, José Manuel
A1 Cores Bartolomé, Carlos
A1 Planellás, Lluis L.
A1 García Caldentey, Juan
A1 Caballol, Núria
A1 Legarda, Inés
A1 Cabo López, Iria
A1 López Manzanares, Lydia
A1 Ávila Rivera, María A.
A1 Catalán, María José
A1 Nogueira, Víctor
A1 Borrue, Carmen
A1 Álvarez Saúco, María
A1 Vela Desojo, Lydia
A1 Cubo Delgado, Esther
A1 Martínez Castrillo, Juan Carlos
A1 Sánchez Alonso, Pilar
A1 Alonso Losada, María Gema
A1 López Ariztegui, Nuria
A1 Gastón, Itziar
A1 Kulisevsky Bojarsky, Jaume
A1 Pagonabarraga, Javier
A1 Seijo, Manuel
A1 Ruíz Martínez, Javier
A1 Valero, Caridad
A1 Kurtis, Mónica M.
A1 González Ardura, Jessica
A1 Prieto, Cristina
A1 Mir, Pablo
A1 Martínez Martín, Pablo
A1 COPPADIS Study Group
K1 Non-motor symptoms
K1 Parkinson’s disease
K1 Parkinson’s disease sleep scale
K1 Quality of life
K1 Sleep
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB Introduction:The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients.Methods:PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson’s disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems.Results:The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 ± 28.8 vs 132.8 ± 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 ± 14 vs 13 ± 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 ± 0.5 vs 3.9 ± 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015–1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009–1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments.Conclusion:Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.
PB SAGE Publications
SN 0891-9887
YR 2020
FD 2020-10
LK http://hdl.handle.net/10259/8803
UL http://hdl.handle.net/10259/8803
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 24-nov-2024