RT info:eu-repo/semantics/article
T1 Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up
A1 Santos García, Diego
A1 Naya Ríos, Lucía
A1 Deus-Fonticoba, Teresa de
A1 Cores Bartolomé, Carlos
A1 García Roca, Lucía
A1 Feal Painceiras, María
A1 Martínez Miró, Cristina
A1 Canfield, Héctor
A1 Jesús, Silvia
A1 Aguilar, Miquel
A1 Pastor, Pau
A1 Cosgaya, Marina
A1 García Caldentey, Juan
A1 Caballol, Núria
A1 Legarda, Inés
A1 Hernández Vara, Jorge
A1 Cabo López, Iria
A1 López Manzanares, Lydia
A1 González Aramburu, Isabel
A1 Ávila Rivera, María A.
A1 Gómez Mayordomo, Víctor
A1 Nogueira, Víctor
A1 Puente, Víctor
A1 Dotor, Julio
A1 Borrue, Carmen
A1 Solano Vila, Berta
A1 Álvarez Saúco, María
A1 Vela Desojo, Lydia
A1 Escalante Arroyo, Sonia
A1 Cubo Delgado, Esther
A1 Carrillo Padilla, Francisco
A1 Martínez Castrillo, Juan Carlos
A1 Sánchez Alonso, Pilar
A1 Alonso Losada, María Gema
A1 López Ariztegui, Nuria
A1 Gastón, Itziar
A1 Kulisevsky Bojarsky, Jaume
A1 Blázquez Estrada, Marta
A1 Seijo, Manuel
A1 Ruíz Martínez, Javier
A1 Valero, Caridad
A1 Kurtis, Mónica M.
A1 Fabregues, Oriol de
A1 González Ardura, Jessica
A1 Alonso Redondo, Rubén
A1 Ordás Bandera, Carlos Manuel
A1 López Díaz, Luis M.
A1 McAfee, Darrian
A1 Martínez Martín, Pablo
A1 Mir, Pablo
K1 Changes
K1 Motor
K1 Parkinson’s disease
K1 Phenotype
K1 PIGD
K1 Tremor
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity.
PB MDPI
YR 2021
FD 2021-12
LK http://hdl.handle.net/10259/8811
UL http://hdl.handle.net/10259/8811
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 24-nov-2024