RT info:eu-repo/semantics/article T1 Cybersickness. A systematic literature review of adverse effects related to virtual reality T2 Ciberenfermedad. Revisión sistemática de la literatura sobre efectos adversos asociados a la Realidad Virtual A1 Simón Vicente, Lucía A1 Rodríguez Cano, Sonia A1 Delgado Benito, Vanesa A1 Ausín Villaverde, Vanesa A1 Cubo Delgado, Esther K1 Virtual reality K1 Side effects K1 Cybersickness K1 Simulator Sickness K1 Questionnaire K1 Realidad virtual K1 Efectos secundarios K1 Ciberenfermedad K1 Cuestionario K1 Sistema nervioso-Enfermedades K1 Nervous system-Diseases K1 Medicina K1 Medicine K1 Neurología K1 Neurology AB Background: Virtual Reality (VR) uses computer technology to create a simulated environment.VR is a growing technology with promising extensive applications in different areas such asMedicine, entertainment, sports, gaming, and simulation. However, information about VR sideeffects is still limited. We aimed to identify the most frequent physical side effects caused byVR therapeutic applications.Methodology: All available full-text articles evaluating VR as a therapeutic intervention andside effects using the Simulator Sickness Questionnaire (SSQ) between 2016 and 2021 wereconsulted across 4 electronic (Entrez Pubmed, Scopus, Science Direct, and Wiley databases).The methodological quality was assessed using the PEDro scale.Results: Ten out of 55 reviewed articles (18%) met inclusion/exclusion criteria, including asample of 416 patients, mean age of 24.54 (15—52.6) years old. According to the PEDro scale,two articles (20%) were considered good or excellent. Side effects were reported more frequently with head-mounted displays compared to desktop systems, especially disorientation,followed by nausea and oculomotor disturbances.Conclusions: Although VR might have positive effects as a therapeutic tool, VR can also causeside events. As in any othertherapeutic intervention, itis importantto understand the effectiveness and safety before planning a VR intervention using a well-designed scientific methodology. PB Elsevier SN 0213-4853 YR 2022 FD 2022-07 LK http://hdl.handle.net/10259/8824 UL http://hdl.handle.net/10259/8824 LA eng NO The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was co-financed by the Erasmus+ program of the European Union through the 2018-1-ES01-KA201-050659 project. DS Repositorio Institucional de la Universidad de Burgos RD 09-may-2024