RT info:eu-repo/semantics/article T1 Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease A1 Santos García, Diego A1 Laguna, Ariadna A1 Hernández Vara, Jorge A1 Deus-Fonticoba, Teresa de A1 Cores Bartolomé, Carlos A1 Feal Painceiras, María A1 Íñiguez Alvarado, María Cristina A1 García Díaz, Iago A1 Jesús, Silvia A1 Buongiorno, María Teresa A1 Planellás, Lluis L. A1 Cosgaya, Marina A1 García Caldentey, Juan A1 Caballol, Núria A1 Legarda, Inés A1 Cabo López, Iria A1 López Manzanares, Lydia A1 González Aramburu, Isabel A1 Ávila Rivera, María A. A1 Gómez Mayordomo, Víctor A1 Nogueira, Víctor A1 Puente, Víctor A1 Dotor, Julio A1 Borrue, Carmen A1 Solano Vila, Berta A1 Álvarez Saúco, María A1 Vela Desojo, Lydia A1 Escalante Arroyo, Sonia A1 Cubo Delgado, Esther A1 Carrillo Padilla, Francisco A1 Martínez Castrillo, Juan Carlos A1 Sánchez Alonso, Pilar A1 Alonso Losada, María Gema A1 López Ariztegui, Nuria A1 Gastón, Itziar A1 Kulisevsky Bojarsky, Jaume A1 Menéndez González, Manuel A1 Seijo, Manuel A1 Ruíz Martínez, Javier A1 Valero, Caridad A1 Kurtis, Mónica M. A1 González Ardura, Jessica A1 Alonso Redondo, Rubén A1 Ordás Bandera, Carlos Manuel A1 López Díaz, Luis M. A1 McAfee, Darrian A1 Martínez Martín, Pablo A1 Mir, Pablo A1 COPPADIS Study Group K1 Motor K1 Non-motor symptoms K1 Gender K1 Parkinson’s disease K1 Quality of life K1 Sex K1 Sistema nervioso-Enfermedades K1 Nervous system-Diseases K1 Medicina K1 Medicine K1 Neurología K1 Neurology AB Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed. PB MDPI YR 2023 FD 2023-02 LK http://hdl.handle.net/10259/8827 UL http://hdl.handle.net/10259/8827 LA eng NO COPPADIS and the present study were developed with the help of Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético ( https://fundaciondegen.org/) and Alpha Bioresearch (www.alphabioresearch.com). Also, we received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017–2020 por el proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”) to develop a part of the COPPADIS project. DS Repositorio Institucional de la Universidad de Burgos RD 24-nov-2024