RT info:eu-repo/semantics/article T1 Changes in Principal Caregiver Mood Affects the Mood of the Parkinson’s Disease Patient: The Vicious Cycle of Illness A1 Santos García, Diego A1 Deus-Fonticoba, Teresa de A1 Cores Bartolomé, Carlos A1 Feal Painceiras, María A1 Íñiguez Alvarado, María Cristina A1 García Díaz, Iago A1 Jesús, Silvia A1 Buongiorno, María Teresa A1 Planellás, Lluis L. A1 Cosgaya, Marina A1 García Caldentey, Juan A1 Caballol, Núria A1 Legarda, Inés A1 Hernández Vara, Jorge A1 Cabo López, Iria A1 López Manzanares, Lydia A1 González Aramburu, Isabel A1 Ávila Rivera, María A. A1 Gómez Mayordomo, Víctor A1 Nogueira, Víctor A1 Puente, Víctor A1 Dotor, Julio A1 Borrue, Carmen A1 Solano Vila, Berta A1 Álvarez Saúco, María A1 Vela Desojo, Lydia A1 Escalante Arroyo, Sonia A1 Cubo Delgado, Esther A1 Carrillo Padilla, Francisco A1 Martínez Castrillo, Juan Carlos A1 Sánchez Alonso, Pilar A1 Alonso Losada, María Gema A1 López Ariztegui, Nuria A1 Gastón, Itziar A1 Kulisevsky Bojarsky, Jaume A1 Menéndez González, Manuel A1 Seijo, Manuel A1 Ruíz Martínez, Javier A1 Valero, Caridad A1 Kurtis, Mónica M. A1 González Ardura, Jessica A1 Alonso Redondo, Rubén A1 Ordás Bandera, Carlos Manuel A1 López Díaz, Luis M. A1 McAfee, Darrian A1 Martínez Martín, Pablo A1 Mir, Pablo A1 COPPADIS Study Group K1 Caregiver K1 Longitudinal K1 Mood K1 Parkinson’s disease K1 Quality of life K1 Sistema nervioso-Enfermedades K1 Nervous system-Diseases K1 Medicina K1 Medicine K1 Neurología K1 Neurology AB Background: Although many studies have analyzed what factors contribute to caregiver burden in Parkinson’s disease (PD),there is currently no knowledge about how the status of the caregiver could impact the patient.Objective: The aim of this study was to analyze how the change in the caregiver’s status influences PD patients.Methods: PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centersin Spain from the COPPADIS cohort were included in the study (V0). They were evaluated again at 2-year follow-up(V2). Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at V0 and V2. Multivariate models wereused to analyze the impact of the change from V0 to V2 () on the caregiver’s status over the change in the patient’sstatus.Results: BDI-II and EUROHIS-QOL8 in the caregiver predicted BDI-II ( = 0.32; p < 0.0001; R2 = 0.71) andEUROHIS-QOL8 ( = 0.39; p < 0.0001; R2 = 0.68) in the patient, respectively. Variables related to the caregiver werenot associated with changes in the patient´s health-related QoL (PDQ-39 [39-item Parkinson’s disease Questionnaire]) orautonomy for activities of daily-living (ADLS [Schwab & England Activities of Daily Living Scale]).Conclusion: The change in the caregiver’s mood and global QoL was associated with the change in the patient’s mood andglobal QoL, respectively, independently of other variables of the disease influencing both patient´s aspects. Based on thisfinding, it could be of great importance to detect depression in the principal caregiver of a patient and act on it as earlier aspossible. PB IOS Press SN 1877-7171 YR 2023 FD 2023-03 LK http://hdl.handle.net/10259/8856 UL http://hdl.handle.net/10259/8856 LA eng DS Repositorio Institucional de la Universidad de Burgos RD 08-may-2024