RT info:eu-repo/semantics/article
T1 Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
A1 Kim, Jonggeol Jeffrey
A1 Vitale, Dan
A1 Véliz Otani, Diego
A1 Lian, Michelle Mulan
A1 Heilbron, Karl
A1 23andMe Research Team
A1 Iwaki, Hirotaka
A1 Lake, Julie
A1 Warly Solsberg, Caroline
A1 Leonard, Hampton
A1 Makarious, Mary B.
A1 Tan, Eng-King
A1 Singleton, Andrew B.
A1 Bandres-Ciga, Sara
A1 Noyce, Alastair J.
A1 Cubo Delgado, Esther
A1 Global Parkinson's Genetics Program
A1 Blauwendraat, Cornelis
A1 Nalls, Mike A.
A1 Nee Foo, Jia
A1 Mata, Ignacio
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations.
PB Springer Nature
SN 1546-1718
YR 2023
FD 2023-12
LK http://hdl.handle.net/10259/8858
UL http://hdl.handle.net/10259/8858
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 25-dic-2024