RT info:eu-repo/semantics/article
T1 Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes
A1 Fernández Pampín, Natalia
A1 González Plaza, Juan José
A1 García Gómez, Alejandra
A1 Peña, Elisa
A1 Rumbo Lorenzo, Carlos
A1 Barros García, Rocío
A1 Martel Martín, Sonia
A1 Aparicio Martínez, Santiago
A1 Tamayo Ramos, Juan Antonio
K1 Química física
K1 Chemistry, Physical and theoretical
AB In the present study, a comparative human toxicity assessment between newly developed Mn3O4 nanoparticles with enhanced electrochemical properties (GNA35) and their precursor material (Mn3O4) was performed, employing different in vitro cellular models representing main exposure routes (inhalation, intestinal and dermal contact), namely the human alveolar carcinoma epithelial cell line (A549), the human colorectal adenocarcinoma cell line (HT29), and the reconstructed 3D human epidermal model EpiDerm. The obtained results showed that Mn3O4 and GNA35 harbour similar morphological characteristics, whereas differences were observed in relation to their surface area and electrochemical properties. In regard to their toxicological properties, both nanomaterials induced ROS in the A549 and HT29 cell lines, while cell viability reduction was only observed in the A549 cells. Concerning their skin irritation potential, the studied nanomaterials did not cause a reduction of the skin tissue viability in the test conditions nor interleukin 1 alpha (IL- 1 α) release. Therefore, they can be considered as not irritant nanomaterials according to EU and Globally Harmonized System of Classification and Labelling Chemicals. Our findings provide new insights about the potential harmful effects of Mn3O4 nanomaterials with different properties, demonstrating that the hazard assessment using different human in vitro models is a critical aspect to increase the knowledge on their potential impact upon different exposure routes.
PB Springer Nature
YR 2022
FD 2022-12-05
LK http://hdl.handle.net/10259/9493
UL http://hdl.handle.net/10259/9493
LA eng
NO This work was supported by the Junta de Castilla y Leon-FEDER grant N° BU058P20 (NANOCOMP), and by the European Union’s H2020 research and innovation programme, under the grant agreements N° 952379 (SURFBIO), and N° 953152 (DIAGONAL).
DS Repositorio Institucional de la Universidad de Burgos
RD 11-dic-2024