RT info:eu-repo/semantics/article
T1 Hybrid Hydroxyapatite–Metal Complex Materials Derived from Amino Acids and Nucleobases
A1 Jiménez Pérez, Alondra
A1 Martínez Alonso, Marta
A1 García Tojal, Javier
K1 Amino acid
K1 Calcium phosphate
K1 Hybrid material
K1 Nucleobase
K1 Hydroxyapatite
K1 Nucleic acid
K1 Peptide
K1 Protein
K1 Bioquímica
K1 Biochemistry
K1 Química inorgánica
K1 Chemistry, Inorganic
AB Calcium phosphates (CaPs) and their substituted derivatives encompass a large number of compounds with a vast presence in nature that have aroused a great interest for decades. In particular, hydroxyapatite (HAp, Ca10(OH)2(PO4)6) is the most abundant CaP mineral and is significant in the biological world, at least in part due to being a major compound in bones and teeth. HAp exhibits excellent properties, such as safety, stability, hardness, biocompatibility, and osteoconductivity, among others. Even some of its drawbacks, such as its fragility, can be redirected thanks to another essential feature: its great versatility. This is based on the compound’s tendency to undergo substitutions of its constituent ions and to incorporate or anchor new molecules on its surface and pores. Thus, its affinity for biomolecules makes it an optimal compound for multiple applications, mainly, but not only, in biological and biomedical fields. The present review provides a chemical and structural context to explain the affinity of HAp for biomolecules such as proteins and nucleic acids to generate hybrid materials. A size-dependent criterium of increasing complexity is applied, ranging from amino acids/nucleobases to the corresponding macromolecules. The incorporation of metal ions or metal complexes into these functionalized compounds is also discussed.
PB MDPI
YR 2024
FD 2024-09
LK http://hdl.handle.net/10259/9756
UL http://hdl.handle.net/10259/9756
LA eng
NO Artículo de revisión
NO This research was funded by the European Union, NMBP-16-2020-GA 953152 DIAGONAL. M.M.-A. acknowledges funding from the European Union—NextGenerationEU through her María Zambrano postdoctoral grant. A.J.-P. wishes to thank the Consejería de Educación de la Junta de Castilla y León and the Fondo Social Europeo Plus (FSE+) for her predoctoral contract and the International Research Center in Critical Raw Materials for Advanced Industrial Technologies (ICCRAM) for financial support.
DS Repositorio Institucional de la Universidad de Burgos
RD 12-dic-2024