RT info:eu-repo/semantics/article
T1 Desulfurization of thiosemicarbazones: the role of metal ions and biological implications
A1 Jiménez Pérez, Alondra
A1 Fernández-Fariña, Sandra
A1 Pedrido Castiñeiras, Rosa
A1 García Tojal, Javier
K1 Antitumor
K1 Biological activity
K1 Cyclization
K1 Desulfurization
K1 Metal complexes
K1 Thiosemicarbazone
K1 Química inorgánica
K1 Chemistry, Inorganic
AB Thiosemicarbazones are biologically active substances whose structural formula is formed by an azomethine, an hydrazine, and a thioamide fragments, to generate a R2C=N–NR–C(=S)–NR2 backbone. These compounds often act as ligands to generate highly stable metal–organic complexes. In certain experimental conditions, however, thiosemicarbazones undergo reactions leading to the cleavage of the chain. Sometimes, the breakage involves desulfurization processes. The present work summarizes the different chemical factors that influence the desulfurization reactions of thiosemicarbazones, such as pH, the presence of oxidant reactants or the establishment of redox processes as those electrochemically induced, the effects of the solvent, the temperature, and the electromagnetic radiation. Many of these reactions require coordination of thiosemicarbazones to metal ions, even those present in the intracellular environment. The nature of the products generated in these reactions, their detection in vivo and in vitro, together with the relevance for the biological activity of these compounds, mainly as antineoplastic agents, is discussed.
PB Springer
YR 2023
FD 2023-12
LK http://hdl.handle.net/10259/9757
UL http://hdl.handle.net/10259/9757
LA eng
NO Artículo de revisión
NO This work was supported by European Union  H2020-LC-SC3-2020-NZE-RES-CC  NEFERTITI, NMBP-16- 2020-GA 953152 DIAGONAL, DT-NMBP-04-2020-GA 952941  BIOMAC and HORIZON-CL4-2021-RESILIENCE-01-12 Projects,  together with Ministerio de Ciencia, Innovación y Universidades  PID2021-127531NB-I00 (AEI/https://doi.org/10.13039/5011000110 33/FEDER, UE) and CTQ(QMC) RED2018-102471-T MultiMetDrugs  Network (Spain), Consejería de Educación de la Junta de Castilla y  León and FEDER BU049P20, Consellería de Cultura, Educación e  Ordenación Universitaria, Xunta de Galicia GRC GI-1584 (ED431C  2023/02). AJP wishes to thank the Consejería de Educación de la Junta  de Castilla y León and the Fondo Social Europeo Plus (FSE+) for her  Doctoral Contract and to ICCRAM for the fnancial support.
DS Repositorio Institucional de la Universidad de Burgos
RD 12-dic-2024